{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:46:46Z","timestamp":1781887606723,"version":"3.54.5"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T00:00:00Z","timestamp":1427673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Oral mucositis (OM) is considered a painful and debilitating side effect in patients receiving head and neck cancer treatment. Low\u2010level laser therapy (LLLT) proved to be effective to prevent and treat chemoradiotherapy\u2010induced OM. The aim of this study was to evaluate the effect of LLLT in the severity of OM in patients with head and neck cancer and on the release of salivary inflammatory mediators. Clinical (score of OM severity) and biochemical parameters (concentration of inflammatory mediators, growth factors, and enzymes in saliva) were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty patients were randomized into two groups: control and laser. LLLT was performed three times a week in the laser group, while control group received sham irradiation. OM severity was assessed according to the World Health Organization (WHO) and National Cancer Institute (NCI) scales. Pro\u2010inflammatory and anti\u2010inflammatory cytokines (TNF\u2010\u03b1, IL\u20106, IL\u20101\u03b2, IL\u201010, TGF\u2010\u03b2), growth factors (EGF, FGF, VEGF), and metalloproteinases (MMP2\/TIMP2, MMP9\/TIMP2) concentrations were assessed using ELISA test. Saliva samples were collected on admission, and at the 7th, 21st, and 35th sessions of radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The laser group showed a reduction in the severity of OM, which coursed with significantly diminished salivary concentration of EGF and VEGF in the 7th radiotherapy session and of IL\u20106 and FGF in the 35th. There was a trend for reduced levels of IL\u20101\u03b2, TNF\u2010\u03b1, IL\u201010, TGF\u2010\u03b2, MMP2\/TIMP2, MMP9\/TIMP2 in the laser group compared to the control, however, no statistically significant differences were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings demonstrated that LLLT was effective in reducing the severity of chemoradiotherapy\u2010induced OM and was associated with the reduction of inflammation and repair. Lasers Surg. Med. 47:296\u2013305, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22349","type":"journal-article","created":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T16:53:28Z","timestamp":1427820808000},"page":"296-305","source":"Crossref","is-referenced-by-count":95,"title":["Effect of low\u2010level laser therapy on chemoradiotherapy\u2010induced oral mucositis and salivary inflammatory mediators in head and neck cancer patients"],"prefix":"10.1002","volume":"47","author":[{"given":"Ang\u00e9lica F.","family":"Oton\u2010Leite","sequence":"first","affiliation":[{"name":"Department of Oral Medicine (Oral Pathology) Dental School Federal University of Goi\u00e1s Goi\u00e2nia Goi\u00e1s 74605\u2010220 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geisa Badauy L.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine (Oral Pathology) Dental School Federal University of Goi\u00e1s Goi\u00e2nia Goi\u00e1s 74605\u2010220 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia O.","family":"Morais","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine (Oral Pathology) Dental School Federal University of Goi\u00e1s Goi\u00e2nia Goi\u00e1s 74605\u2010220 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarc\u00edlia A.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine (Oral Pathology) Dental School Federal University of Minas Gerais Belo Horizonte Minas Gerais 31270\u2010901 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio R.","family":"Leles","sequence":"additional","affiliation":[{"name":"Department of Prevention and Oral Rehabilitation, Dental School Federal University of Goi\u00e1s Goi\u00e2nia Goi\u00e1s 74605\u2010220 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marize Campos","family":"Valadares","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Pharmacology and Toxicology Faculty of Pharmacy Federal University of Goi\u00e1s Goi\u00e2nia Goi\u00e1s 74605\u2010220 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Castro D.","family":"Pinezi","sequence":"additional","affiliation":[{"name":"Radiotherapy Department of the Ara\u00fajo Jorge Hospital Association of Cancer Combat of Goi\u00e1s Goi\u00e2nia Goi\u00e1s 74605\u2010070 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline C.","family":"Batista","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine (Oral Pathology) Dental School Federal University of Goi\u00e1s Goi\u00e2nia Goi\u00e1s 74605\u2010220 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elismauro F.","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine (Oral Pathology) 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