{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T14:19:15Z","timestamp":1721485155287},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swiss National Foundation","award":["3200030","135197"],"award-info":[{"award-number":["3200030","135197"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Low\u2010dose, Visudyne\u00ae\u2010mediated photodynamic therapy (photo\u2010induction) was shown to selectively enhance tumor vessel transport causing increased uptake of systemically administered chemotherapy in various tumor types grown on rodent lungs. The present experiments explore the efficacy of photo\u2010induced vessel modulation combined to intravenous (IV) liposomal cisplatin (Lipoplatin\u00ae) on rodent lung tumors and the feasibility\/toxicity of this approach in porcine chest cavities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Three groups of Fischer rats underwent orthotopic sarcoma (<jats:italic>n<\/jats:italic>\u2009=\u200914), mesothelioma (<jats:italic>n<\/jats:italic>\u2009=\u200914), or adenocarcinoma (<jats:italic>n<\/jats:italic>\u2009=\u200912) implantation on the left lung. Half of the animals of each group had photo\u2010induction (0.0625\u2009mg\/kg Visudyne\u00ae, 10\u2009J\/cm<jats:sup>2<\/jats:sup>) followed by IV administration of Lipoplatin\u00ae (5\u2009mg\/kg) and the other half received Lipoplatin\u00ae without photo\u2010induction. Then, two groups of minipigs underwent intrapleural thoracoscopic (VATS) photo\u2010induction (0.0625\u2009mg\/kg Visudyne\u00ae; 30\u2009J\/cm<jats:sup>2<\/jats:sup> hilum; 10\u2009J\/cm<jats:sup>2<\/jats:sup> apex\/diaphragm) with <jats:italic>in situ<\/jats:italic> light dosimetry in combination with IV Lipoplatin\u00ae administration (5\u2009mg\/kg). Protocol I (<jats:italic>n<\/jats:italic>\u2009=\u20096) received Lipoplatin\u00ae immediately after light delivery and Protocol II (<jats:italic>n<\/jats:italic>\u2009=\u20099) 90\u2009minutes before light delivery. Three additional animals received Lipoplatin\u00ae and VATS pleural biopsies but no photo\u2010induction (controls). Lipoplatin\u00ae concentrations were analyzed in blood and tissues before and at regular intervals after photo\u2010induction using inductively coupled plasma mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Photo\u2010induction selectively increased Lipoplatin\u00ae uptake in all orthotopic tumors. It significantly increased the ratio of tumor to lung Lipoplatin\u00ae concentration in sarcoma (<jats:italic>P<\/jats:italic>\u2009=\u20090.0008) and adenocarcinoma (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) but not in mesothelioma, compared to IV drug application alone. In minipigs, intrapleural photo\u2010induction combined to systemic Lipoplatin\u00ae was well tolerated with no toxicity at 7 days for both treatment protocols. The pleural Lipoplatin\u00ae concentrations were not significantly different at 10 and 30\u2009J\/cm<jats:sup>2<\/jats:sup> locations but they were significantly higher in protocol I compared to II (2.37\u2009\u00b1\u20090.7 vs. 1.37\u2009\u00b1\u20090.7\u2009ng\/mg, <jats:italic>P<\/jats:italic>\u2009 &lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Visudyne\u00ae\u2010mediated photo\u2010induction selectively enhances the uptake of IV administered Lipoplatin\u00ae in rodent lung tumors. Intrapleural VATS photo\u2010induction with identical treatment conditions combined to IV Lipoplatin chemotherapy is feasible and well tolerated in a porcine model. Lasers Surg. Med. 47:807\u2013816, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22422","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T20:03:02Z","timestamp":1443470582000},"page":"807-816","source":"Crossref","is-referenced-by-count":5,"title":["Treatment of pleural malignancies by photo\u2010induction combined to systemic chemotherapy: Proof of concept on rodent lung tumors and feasibility study on porcine chest cavities"],"prefix":"10.1002","volume":"47","author":[{"given":"Xingyu","family":"Wang","sequence":"first","affiliation":[{"name":"Departement of Thoracic Surgery Centre Hospitalier Universitaire Vaudois Lausanne VD Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Gronchi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Centre Hospitalier Universitaire Vaudois Lausanne VD 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