{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:42:39Z","timestamp":1791063759615,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Photo\u2010aging in Chinese often presents with benign pigmentary lesions. Q\u2010switched lasers for pigmentary lesions in Asians had reported a risk of post\u2010inflammatory hyperpigmentation (PIH) up to 25%. Longer pulse widths in the millisecond domains were advocated with reduced risk of PIH. Recently, picosecond lasers of various wavelengths were introduced with proven efficacy in tattoo removal. The objective of this study is to assess the efficacy and safety of a novel picosecond 755\u2010nm alexandrite laser for the treatment of benign pigmented lesions in Asians retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A list of all patients who received picosecond 755\u2010nm alexandrite laser treatment at a private dermatology center in Hong Kong was included. Those who had any other laser or topical treatment during the period of picosecond laser treatment were excluded. The age, skin phototype, type of pigmentary lesion, number of treatments performed was recorded. The baseline and most recent standardized photographs were assessed by trained physicians for comparison. A score of 0\u20134, representing poor 0\u201324%, fair 25\u201349%, good 50\u201374%, excellent 75\u201395%, and complete 95%+ improvement was given. Adverse events associated with the laser treatment were also recorded. All patients were followed up until 6 months after the last laser session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 13 subjects were included in the present study. The number of treatment sessions received ranged from one to seven. The benign pigmentary lesions consist of Nevus of Ota, caf\u00e9\u2010au\u2010lait patches, lentigines, Becker's nevus, Hori's macules, and nevus spilus. Among patients with Nevus of Ota, one patient achieved complete clearance after four treatments and two other patients had excellent clearance after three and four sessions, respectively. Patients with caf\u00e9\u2010au\u2010lait had fair to good clearance after one to seven treatment sessions. One patient who has Hori's macules was resistant to laser treatments and a fair response was achieved after eight treatments. In the present series, two patients (4.8%) developed transient hypopigmentation, which had improved upon subsequent follow\u2010up in both cases and none had post\u2010inflammatory hyperpigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel picosecond 755\u2010nm alexandrine laser is effective for the treatment of benign pigmentary lesions in Chinese, especially for the clearance of Nevus of Ota. Picosecond laser appears to be associated with a much lower risk of PIH for treatment of pigmentary lesions in Asians. Lasers Surg. Med. 48:23\u201329, 2016. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22443","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T17:25:21Z","timestamp":1450805121000},"page":"23-29","source":"Crossref","is-referenced-by-count":114,"title":["A retrospective analysis on the management of pigmented lesions using a picosecond 755\u2010nm alexandrite laser in Asians"],"prefix":"10.1002","volume":"48","author":[{"given":"Johnny Chun\u2010yin","family":"Chan","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Medicine The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha Yee\u2010nam","family":"Shek","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Tokai University Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Keung","family":"Yeung","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry Hin\u2010lee","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine The University of Hong Kong Hong Kong SAR China"},{"name":"Wellman Center for Photomedicine Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20942"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.2.167"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.2894"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.901"},{"key":"e_1_2_5_6_1","unstructured":"TanghettiEA TanghettiM. 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