{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:54:58Z","timestamp":1778774098222,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Photodynamic therapy (PDT) has been used as a therapeutic alternative to treat periodontitis, especially in challenging sites that require additional periodontal therapy such as residual pockets. The aim of this split\u2010mouth randomized trial was to evaluate the microbiological and clinical effects of PDT on non\u2010surgical treatment of unresponsive pockets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>A split\u2010mouth, randomized controlled clinical trial was conducted in 15 patients presenting at least two residual pockets (probing pocket depth [PPD] \u22655\u2009mm with bleeding on probing [BoP]) in single\u2010rooted teeth in supportive periodontal therapy. The selected sites randomly received: (1) SRP\u2009+\u2009PDT: scaling and root planing combined with photodynamic therapy (methylene blue as a photosensitizer), or (2) SRP: scaling and root planing alone. The concentrations of <jats:italic>Porphyromonas gingivalis<\/jats:italic> and <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> were evaluated using a Real\u2010time PCR technique at baseline and 3, 7, 14, and 90 days. Clinical parameters were assessed at baseline and 3 months post\u2010therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both treatments promoted clinical improvements, with additional benefits to the SRP\u2009+\u2009PDT group in PPD reduction and clinical attachment level gain (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) after 3 months. Only the SRP\u2009+\u2009PDT group exhibited a statistically significant reduction in the levels of <jats:italic>A. actinomycetemcomitans<\/jats:italic> on the 3rd and 7th days after therapy (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and a lower concentration of this pathogen was detected at 7 days in the SRP\u2009+\u2009PDT group when compared to the other therapy (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combined therapeutic approach SRP\u2009+\u2009PDT may reduce <jats:italic>A. actinomycetemcomitans<\/jats:italic> levels for a short\u2010term period, associated with additional improvement in clinical parameters in treating residual pockets. Lasers Surg. Med. 48:944\u2013950, 2016. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22449","type":"journal-article","created":{"date-parts":[[2015,12,13]],"date-time":"2015-12-13T03:16:27Z","timestamp":1449976587000},"page":"944-950","source":"Crossref","is-referenced-by-count":41,"title":["Short\u2010term microbiological effects of photodynamic therapy in non\u2010surgical periodontal treatment of residual pockets: A split\u2010mouth RCT"],"prefix":"10.1002","volume":"48","author":[{"given":"M\u00f4nica Grazieli","family":"Corr\u00eaa","sequence":"first","affiliation":[{"name":"Dental Research Division School of Dentistry Paulista University S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah Haydee","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Dental Research Division School of Dentistry Paulista University S\u00e3o Paulo S\u00e3o Paulo 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