{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:54:06Z","timestamp":1790794446186,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,28]],"date-time":"2016-02-28T00:00:00Z","timestamp":1456617600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Laser procedures in skin of color (SOC) patients are challenging due to the increased risk of dyspigmentation and scarring. A novel 755\u2009nm alexandrite picosecond laser has demonstrated effectiveness for tattoo removal and treatment of acne scars. No studies to date have evaluated its applications in pigmentary disorders. The purpose of this retrospective study was to evaluate the safety profile and efficacy of the picosecond alexandrite laser compared to the current standard treatment, Q\u2010switched ruby and neodynium (Nd):YAG nanosecond lasers, for pigmentary disorders in SOC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>A retrospective photographic and chart evaluation of seventy 755\u2009nm alexandrite picosecond, ninety\u2010two Q\u2010switched frequency doubled 532\u2009nm and 1,064\u2009nm Nd:YAG nanosecond, and forty\u2010seven Q\u2010switched 694\u2009nm ruby nanosecond laser treatments, in forty\u2010two subjects of Fitzpatrick skin types III\u2013VI was conducted in a single laser specialty center. The picosecond laser was a research prototype device. Treatment efficacy was assessed by two blinded physician evaluators, using a visual analog scale for percentage of pigmentary clearance in standard photographs. Subject assessment of efficacy, satisfaction, and adverse events was performed using a questionnaire survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common pigmentary disorder treated was Nevus of Ota (38.1%), followed by solar lentigines (23.8%). Other pigmentary disorders included post\u2010inflammatory hyperpigmentation, congenital nevus, caf\u00e9 au lait macule, dermal melanocytosis, Nevus of Ito, and Becker's nevus. Clinical efficacy of the Q\u2010switched nanosecond lasers and picosecond laser treatments were comparable for lesions treated on the face with a mean visual analog score of 2.57 and 2.44, respectively, corresponding to approximately 50% pigmentary clearance. Subject questionnaires were completed in 58.8% of the picosecond subjects and 52.0% of the Q\u2010switched subjects. Eighty four percent of subjects receiving Q\u2010switched nanosecond laser treatments and 50% of the subjects receiving alexandrite 755\u2009nm picosecond laser treatments felt satisfied to completely satisfied. Side effects observed in subjects treated with the alexandrite 755\u2009nm picosecond laser were similar to those commonly observed and reported with the nanosecond Q\u2010switched technology. All side effects were temporary, resolving within one month, and no long\u2010term complications were noted. All patients who were very satisfied with their picosecond laser treatment for Nevus of Ota noted a delayed improvement only after 3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 755\u2009nm alexandrite picosecond, 694\u2009nm ruby, 532\u2009nm, and 1064\u2009nm neodynium:YAG nanosecond lasers appear to be safe and effective modalities for removal of pigmentary disorders in skin of color patients with no long\u2010term complications if used appropriately. This study demonstrates the potential of the 755\u2009nm alexandrite picosecond laser in further clinical applications beyond tattoo removal. While the Q\u2010switched lasers were effective, promising results were also observed using an early version of the novel picosecond laser for the removal of pigmentary lesions in SOC patients. As we continue to improve our understanding of the 755\u2009nm picosecond laser, this device may prove to be a safe and effective alternative to the Q\u2010switched lasers for the treatment of facial pigmented lesions in patients with skin of color. Lasers Surg. Med. 48:181\u2013187, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22454","type":"journal-article","created":{"date-parts":[[2016,2,28]],"date-time":"2016-02-28T23:58:06Z","timestamp":1456703886000},"page":"181-187","source":"Crossref","is-referenced-by-count":117,"title":["Treatment of pigmentary disorders in patients with skin of color with a novel 755\u2009nm picosecond, Q\u2010switched ruby, and Q\u2010switched Nd:YAG nanosecond lasers: A retrospective photographic review"],"prefix":"10.1002","volume":"48","author":[{"given":"Melissa Kanchanapoomi","family":"Levin","sequence":"first","affiliation":[{"name":"Laser and Skin Surgery Center of New York New York City 10016 New York"},{"name":"Department of Dermatology The Ronald O. Perelman NYU Langone Medical Center New York City 10016 New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Ng","sequence":"additional","affiliation":[{"name":"Laser and Skin Surgery Center of New York New York City 10016 New York"},{"name":"Department of Dermatology The Ronald O. Perelman NYU Langone Medical Center New York City 10016 New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon\u2010Soo Cindy","family":"Bae","sequence":"additional","affiliation":[{"name":"Laser and Skin Surgery Center of New York New York City 10016 New York"},{"name":"Department of Dermatology The Ronald O. Perelman NYU Langone Medical Center New York City 10016 New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A.","family":"Brauer","sequence":"additional","affiliation":[{"name":"Laser and Skin Surgery Center of New York New York City 10016 New York"},{"name":"Department of Dermatology The Ronald O. Perelman NYU Langone Medical Center New York City 10016 New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy G.","family":"Geronemus","sequence":"additional","affiliation":[{"name":"Laser and Skin Surgery Center of New York New York City 10016 New York"},{"name":"Department of Dermatology The Ronald O. Perelman NYU Langone Medical Center New York City 10016 New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"495A","article-title":"A clini\u2010cohistopathologic study of acne vulgaris in black females","volume":"106","author":"Halder RM","year":"1996","journal-title":"J Invest Dermatol"},{"key":"e_1_2_6_3_1","first-page":"387","article-title":"Common dermatologic disorders in skin of color: A comparative practice survey","volume":"80","author":"Alexis AF","year":"2007","journal-title":"Cutis"},{"key":"e_1_2_6_4_1","unstructured":"United States Census Bureau. Census Explorer: Population Estimates Edition: Total Population.http:\/\/www.census.gov\/censusexplorer\/censusexplorer\u2010popest.html. 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