{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T21:14:18Z","timestamp":1774473258099,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"ZELTIQ Aesthetics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Cryolipolysis is a safe, effective non\u2010surgical procedure to reduce fat. For most cryolipolysis treatments, tissue is pulled between parallel cooling plates with a treatment duration of 60 minutes. A novel contoured cup, medium\u2010sized applicator was developed to increase tissue contact with reduced skin tension and reduced treatment time. This prototype contoured cup was investigated with a standard cryolipolysis applicator to evaluate safety, efficacy, and patient preference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Material and Methods<\/jats:title><jats:p>A prototype CoolCup medium\u2010sized vacuum applicator (CoolSculpting System, ZELTIQ Aesthetics) was used to treat <jats:italic>n<\/jats:italic>\u2009=\u200919 subjects in the flanks. Randomly assigned, one flank received standard treatment with the CoolCore applicator (\u221210\u00b0C for 60 minutes). The contralateral flank received treatment from the CoolCup (\u221211\u00b0C for 35 minutes). The clinical study primary efficacy endpoint was 70% correct identification of baseline photographs by independent physician review. Incidence of adverse device effects was monitored. Fat layer reduction was measured by ultrasound and subject surveys were administered 12 weeks post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Equivalent efficacy was demonstrated between the CoolCore standard treatment and the prototype CoolCup. Independent review from three blinded physicians found 81% correct identification of baseline photographs for the standard treatment and 79% for the CoolCup. Ultrasound measurements indicated mean fat layer reduction of 4.38\u2009mm for the standard treatment and 4.40\u2009mm for the CoolCup; no statistically significant difference was found when comparing treatment efficacy of the two applicators (<jats:italic>P<\/jats:italic>\u2009=\u20090.96). Patient questionnaires revealed 85% preferred CoolCup because of shorter treatment duration and greater comfort. Procedural assessments revealed 45% lower pain scores for CoolCup. Immediate post\u2010treatment clinical assessments revealed 82% less bruising. Typical side effects, such as numbness and erythema, were similar. There were no adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This clinical study of a prototype medium\u2010sized vacuum applicator with a cooled contoured surface indicates that the CoolCup produces equivalent safety and efficacy to the standard CoolCore cryolipolysis applicator. With a 42% reduction in treatment time, the procedure was found to be more comfortable because of lower vacuum skin tension and shorter treatment duration. Lasers Surg. Med. 49:63\u201368, 2017. \u00a9 2016 The Authors. <jats:italic>Lasers in Surgery and Medicine<\/jats:italic> Published by Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22550","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T21:00:01Z","timestamp":1466629201000},"page":"63-68","source":"Crossref","is-referenced-by-count":33,"title":["Prototype CoolCup cryolipolysis applicator with over 40% reduced treatment time demonstrates equivalent safety and efficacy with greater patient preference"],"prefix":"10.1002","volume":"49","author":[{"given":"Suzanne L.","family":"Kilmer","sequence":"first","affiliation":[{"name":"Laser and Skin Surgery Center of Northern California Sacramento California"},{"name":"University of California Davis School of Medicine Davis California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22302"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22320"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.DSS.0000452628.99209.4f"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000415"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2015.1114644"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1781-y"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22440"},{"issue":"26","key":"e_1_2_7_9_1","first-page":"28","article-title":"Safety and efficacy of colder temperature, shorter duration cryolipolysis treatments","volume":"47","author":"Kilmer S","year":"2015","journal-title":"Lasers Surg Med"},{"key":"e_1_2_7_10_1","unstructured":"Treatment parameters for CoolSmooth PRO and CoolMini applicators provided by ZELTIQ Aesthetics Pleasanton CA."}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22550","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22550","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.22550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T05:36:08Z","timestamp":1694496968000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.22550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,21]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/lsm.22550"],"URL":"https:\/\/doi.org\/10.1002\/lsm.22550","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,21]]}}}