{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:04:19Z","timestamp":1780067059982,"version":"3.54.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Infrastructure Program for New-Growth Industries","award":["10044186"],"award-info":[{"award-number":["10044186"]}]},{"name":"Ministry of Trade, Industry & Energy (MI, Korea)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Many studies have investigated the application of micro\u2010insulated needles with radio frequency (RF) to treat acne in humans; however, the use of a micro\u2010insulated needle RF applicator has not yet been studied in an animal model. The purpose of this study was to evaluate the effectiveness of a micro\u2010insulated needle RF applicator in a rabbit ear acne (REA) model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>In this study, we investigated the effect of selectively destroying the sebaceous glands using a micro\u2010insulated needle RF applicator on the formation of comedones induced by application of 50% oleic acid and intradermal injection of<jats:italic>P. acnes<\/jats:italic>in the orifices of the external auditory canals of rabbits. The effects of the micro\u2010insulated needle RF applicator treatment were evaluated using regular digital photography in addition to 3D Primos imaging evaluation, Skin Visio Meter microscopic photography, and histologic analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Use of the micro\u2010insulated needle RF applicator resulted in successful selective destruction of the sebaceous glands and attenuated TNF\u2010alpha release in an REA model. The mechanisms by which micro\u2010insulated needles with RF using 1\u2009MHz exerts its effects may involve inhibition of comedone formation, triggering of the wound healing process, and destruction of the sebaceous glands and papules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of micro\u2010insulated needles with RF applicators provides a safe and effective method for improving the appearance of symptoms in an REA model. The current<jats:italic>in vivo<\/jats:italic>study confirms that the micro\u2010insulated needle RF applicator is selectively destroying the sebaceous glands. Lasers Surg. Med. 49:395\u2013401, 2017. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22599","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T05:28:58Z","timestamp":1475126938000},"page":"395-401","source":"Crossref","is-referenced-by-count":26,"title":["Targeting of sebaceous glands to treat acne by micro\u2010insulated needles with radio frequency in a rabbit ear model"],"prefix":"10.1002","volume":"49","author":[{"given":"Tae\u2010Rin","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ja","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang 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