{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:56:16Z","timestamp":1773298576354,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T00:00:00Z","timestamp":1478044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","award":["N0001681"],"award-info":[{"award-number":["N0001681"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Fractional Er:YAG minimizes the risk associated with skin ablation. Infrared diode laser and radiofrequency have suggested comparable improvements in acne scar. We compared the clinical efficacy of Er:YAG laser and bipolar radiofrequency combined with diode laser (BRDL) for the treatment of acne scars. Moreover, acute molecular changes of cytokine profile associated with wound healing have been evaluated to suggest mechanisms of improvement of acne scar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Twenty\u2010four subjects with mild\u2010to\u2010moderate acne scars were treated in a split\u2010face manner with Er:YAG and BRDL, with two treatment sessions, 4 weeks apart. Objective and subjective assessments were done at baseline, 1, 3, 7 days after each treatment and 4 weeks after last treatment. Skin biopsy specimens were obtained at baseline, 1, 3, 7, 28 days after one session of treatment for investigation of molecular profile of acute skin changes by laser treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Investigator's Global Assessment representing the improvement degree shows 2.1 (50%) in fractional Er:YAG and 1.2 (25%) in BRDL. Er:YAG induced the later and higher peak expression of TGF\u03b2s and collagenases, whereas BRDL induced earlier and lower expression of TGF\u03b2 and collagenases, relatively. PPAR\u03b3 dropped rapidly after a peak in Er:YAG\u2010treated side, which is associated with tissue inhibitor of metalloproteinase (TIMP) expression. We observed higher expression of TIMP after Er:YAG treatment compared with BRDL by immunohistochemistry, which may be associated with the expression of upregulation of collagen fibers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The superior efficacy of Er:YAG to BRDL in the treatment of acne scars may be associated with higher expression of collagen which is associated with differential expression of TGF\u03b2s, collagenases, PPAR\u03b3, and TIMP. Lasers Surg. Med. 49:341\u2013347, 2017. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22607","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T10:10:20Z","timestamp":1478081420000},"page":"341-347","source":"Crossref","is-referenced-by-count":28,"title":["Comparison between Er:YAG laser and bipolar radiofrequency combined with infrared diode laser for the treatment of acne scars: Differential expression of fibrogenetic biomolecules may be associated with differences in efficacy between ablative and non\u2010ablative laser treatment"],"prefix":"10.1002","volume":"49","author":[{"given":"Seonguk","family":"Min","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul South Korea"},{"name":"Acne and Rosacea Research Laboratory, Seoul National University Hospital Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul South Korea"},{"name":"Acne and Rosacea Research Laboratory, Seoul National University Hospital Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungyoon","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul South Korea"},{"name":"Acne and Rosacea Research Laboratory, Seoul National University Hospital Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyuck Hoon","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul South Korea"},{"name":"Acne and Rosacea Research Laboratory, Seoul National University Hospital Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Young","family":"Yoon","sequence":"additional","affiliation":[{"name":"Acne and Rosacea Research Laboratory, Seoul National University Hospital Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Hun","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul South Korea"},{"name":"Acne and Rosacea Research Laboratory, Seoul National University Hospital Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2003.29012.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328243"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2013.807116"},{"key":"e_1_2_6_5_1","article-title":"Effects of laser irradiation at different wavelengths (660, 810, 980, and 1,064 nm) on mucositis in an animal model of wound healing","author":"Usumez A","year":"2013","journal-title":"Lasers Med Sci"},{"key":"e_1_2_6_6_1","first-page":"49","article-title":"Treating acne scars in patients with Fitzpatrick skin types IV to VI using the 1450\u2010nm diode laser","volume":"92","author":"Semchyshyn N","year":"2013","journal-title":"Cutis"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.06.045"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20731"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000096912"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(2000)26:2<215::AID-LSM13>3.0.CO;2-O"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2005.03.032"},{"key":"e_1_2_6_12_1","first-page":"756","article-title":"TGF\u2010beta1, \u2010beta2, and \u2010beta3 in vitro: Biphasic effects on Tenon's fibroblast contraction, proliferation, and migration","volume":"41","author":"Cordeiro MF","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059105"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116906"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000060102.57809.DA"},{"key":"e_1_2_6_16_1","first-page":"717","article-title":"Collagenase\u20103 (MMP\u201013) is expressed during human fetal ossification and re\u2010expressed in postnatal bone remodeling and in rheumatoid arthritis","volume":"76","author":"Stahle\u2010Backdahl M","year":"1997","journal-title":"Lab Invest"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1096\/fsb2fj000588fje"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2011.12.013"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/635912"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013778"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2009.06.032"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24761"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-5-5"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22607","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22607","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.22607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T08:19:10Z","timestamp":1696493950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.22607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,2]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1002\/lsm.22607"],"URL":"https:\/\/doi.org\/10.1002\/lsm.22607","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,2]]}}}