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Fluorescence was recorded intraoperatively using endoscopic equipment. The number and localization, of fluorescing nodules were documented. To analyze sensitivity and specificity samples from fluorescent and non\u2010fluorescent tissues were evaluated histologically. Plasma protoporphyrin concentrations as well as any adverse events were assessed perioperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 26 patients suspected for ovarian cancer underwent intraoperative photodynamic diagnosis with 5\u2010aminolevulinic acid. Most of them suffered from advanced cancer, 72% from FIGO\u2010Stage IIIc. No severe adverse events were observed. Orally applied 5\u2010aminolevulinic acid with a dosage of 1\u2009mg\/kg revealed no detectable fluorescence. However, at a dosage of 10\u2009mg\/kg fluorescence of metastatic tissue was significantly stronger than of non\u2010affected tissue. If administered 4\u20139 hours preoperatively best detection rates for peritoneal metastases were obtained resulting in a sensitivity of 75% and a specificity of 100%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Photodynamic diagnosis with 5\u2010aminolevulinic acid leads to safe and specific fluorescence detection of peritoneal metastases. 5\u2010Aminolevulinic acid should be used at a dosage of at least 10\u2009mg\/kg 4\u20139 hours preoperatively. Further phase I\u2013II studies are recommended. Lasers Surg. Med. 49:169\u2013176, 2017. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22613","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T19:39:46Z","timestamp":1479325186000},"page":"169-176","source":"Crossref","is-referenced-by-count":26,"title":["Photodynamic diagnosis with 5\u2010aminolevulinic acid for intraoperative detection of peritoneal metastases of ovarian cancer: A feasibility and dose finding study"],"prefix":"10.1002","volume":"49","author":[{"given":"Peter","family":"Hillemanns","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Ludwig\u2010Maximilians\u2010University Hospital Munich Germany"},{"name":"Department of Obstetrics and Gynecology Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Wimberger","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology 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