{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:22:52Z","timestamp":1789993372923,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T00:00:00Z","timestamp":1484784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The non\u2010invasive vulvar Paget's disease is an intra\u2010epidermal carcinoma with glandular characteristics. It appears like an erythematous plaque. The main symptoms are pruritus and pain. The standard treatment is surgical excision in depth. This treatment is complicated with a severe morbidity and photodynamic therapy can be an alternative choice. However, the pain experienced during the photodynamic treatment of vulvar lesion is intense and leads to a premature interruption of the treatment. The light emitting fabric is a part of a device under clinical evaluation for the treatment of actinic keratosis with photodynamic therapy. We report the observation of a vulvar Paget's disease treated by this device with a satisfactory result and an excellent tolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Observation<\/jats:title><jats:p>The patient has been diagnosed with non\u2010invasive vulvar Paget's disease for 25 years. The disease recurred constantly despite several imiquimod applications, LASER treatments and conventional photodynamic therapy. These procedures were complicated with intense pain. To improve the tolerance, we performed three PDT sessions a month apart using a 16% methyl\u2010aminolevulinate cream (Metvixia\u00ae Galderma, Lausanne, Switzerland) with the light emitting fabric at low irradiance (irradiance\u2009=\u20096\u2009mW\/cm<jats:sup>2<\/jats:sup>\u2013fluence\u2009=\u200937\u2009J\/cm<jats:sup>2<\/jats:sup>) with a satisfactory result and an excellent tolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>There are no controlled trials evaluating the efficacy of photodynamic therapy in the treatment of vulvar Paget's disease. The treatment and follow\u2010up protocols in the literature are heterogeneous. Pain is the most common side effect with greater intensity for perineal locations where photodynamic therapy is impractical outside of anesthesia or hypnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We report the case of a multirecidivant non\u2010invasive vulvar Paget's disease treated with a satisfactory result and an excellent tolerance by the new light emitting fabric device. A specific study is required but the light emitting fabric could be indicated for the treatment of Paget disease of perineal location. Lasers Surg. Med. 49:177\u2013180, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22631","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T05:52:01Z","timestamp":1484891521000},"page":"177-180","source":"Crossref","is-referenced-by-count":14,"title":["Treatment of a vulvar Paget's disease by photodynamic therapy with a new light emitting fabric based device"],"prefix":"10.1002","volume":"49","author":[{"given":"Claire","family":"Vicentini","sequence":"first","affiliation":[{"name":"Clinic of Dermatology Lille University Hospital Lille France"},{"name":"ONCO\u2010THAI INSERM U1189 Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Carpentier","sequence":"additional","affiliation":[{"name":"Clinic of Dermatology Lille University Hospital Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Lecomte","sequence":"additional","affiliation":[{"name":"ONCO\u2010THAI INSERM U1189 Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Thecua","sequence":"additional","affiliation":[{"name":"ONCO\u2010THAI INSERM U1189 Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Mortier","sequence":"additional","affiliation":[{"name":"Clinic of Dermatology Lille University Hospital Lille France"},{"name":"ONCO\u2010THAI INSERM U1189 Lille France"},{"name":"Lille University Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge R.","family":"Mordon","sequence":"additional","affiliation":[{"name":"ONCO\u2010THAI INSERM U1189 Lille France"},{"name":"Lille University Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(90)90269-Q"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5741"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.04.009"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2012.12.007"},{"key":"e_1_2_5_6_1","article-title":"A phase II study evaluating the non\u2010inferiority of the device FLEXITHERALIGHT\u00ae compared to conventional photodynamic therapy in actinic keratosis treatment","author":"Vicentini C","year":"2016","journal-title":"Oral Communication ASLMS Boston"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70143-2"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2011.10.414"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-11-13"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.04.008"},{"issue":"2","key":"e_1_2_5_11_1","first-page":"229","article-title":"Photodynamic therapy in dermatology, other indications and perspectives","volume":"140","author":"Bedane C","year":"2013","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13138"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08450.x"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22631","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.22631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T05:34:38Z","timestamp":1694496878000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.22631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,19]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1002\/lsm.22631"],"URL":"https:\/\/doi.org\/10.1002\/lsm.22631","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,19]]}}}