{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:58:39Z","timestamp":1773280719830,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T00:00:00Z","timestamp":1494374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011026","name":"DUSA Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Following photodynamic therapy with 5\u2010aminolevulinic acid (ALA\u2010PDT), patients experience inflammation that may be partially attributable to H1 histamine receptor activation. The objective of this study was to evaluate the impact of antihistamines upon adverse effects following ALA\u2010PDT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>This was a randomized, placebo\u2010controlled clinical trial conducted at a single study site. Twenty subjects with facial actinic keratoses were randomized to ALA\u2010PDT plus cetirizine 10\u2009mg (<jats:italic>n<\/jats:italic>\u2009=\u200910) versus placebo daily (<jats:italic>n<\/jats:italic>\u2009=\u200910) from 3 days pre\u2010treatment to 3 days post\u2010treatment for a total of 7 days. Signs of inflammation including erythema, edema, crusting, exudation, vesiculation, and erosion were evaluated on post\u2010treatment days 1, 2, 3, 7, 30, 90, and 180. Actinic keratosis counts, investigator\u2010rated Global Assessment Improvement Score (GAIS), healing, tolerability, and subject satisfaction were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Erythema, edema, crusting, exudation, vesiculation, and erosion were not different between treatment groups. Actinic keratoses were significantly reduced by day 30 in both the antihistamine and placebo groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.01 and 0.0009, respectively), with results sustained to day 60 in the antihistamine group and day 180 for the placebo group. However, counts were not different between groups at any time point. Investigator\u2010rated GAIS, subject satisfaction, healing, and tolerability were similar between treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that while H1 antihistamines do not impair the efficacy of ALA\u2010PDT, they also do not relieve post\u2010treatment inflammation and discomfort. Lasers Surg. Med. 49:738\u2013742, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22682","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T12:52:56Z","timestamp":1494420776000},"page":"738-742","source":"Crossref","is-referenced-by-count":7,"title":["A randomized, double\u2010blind, placebo\u2010controlled clinical trial evaluating the role of systemic antihistamine therapy for the reduction of adverse effects associated with topical 5\u2010aminolevulinic acid photodynamic therapy"],"prefix":"10.1002","volume":"49","author":[{"given":"Monique J.","family":"Vanaman Wilson","sequence":"first","affiliation":[{"name":"Goldman, Butterwick, Groff, Fabi, and Wu Cosmetic Laser Dermatology San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabela T","family":"Jones","sequence":"additional","affiliation":[{"name":"Goldman, Butterwick, Groff, Fabi, and Wu Cosmetic Laser Dermatology San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas C.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchel P.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Goldman, Butterwick, Groff, Fabi, and Wu Cosmetic Laser Dermatology San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700449"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2006.02.006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12562"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12882"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13284"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14465"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.06.051"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2741\/3914"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(01)02050-6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050731"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1586\/eci.10.81"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.1.33"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.22682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T03:56:39Z","timestamp":1696478199000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.22682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,10]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/lsm.22682"],"URL":"https:\/\/doi.org\/10.1002\/lsm.22682","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,10]]}}}