{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:03:49Z","timestamp":1792267429655,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T00:00:00Z","timestamp":1495411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["3200030"],"award-info":[{"award-number":["3200030"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["135197"],"award-info":[{"award-number":["135197"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Low\u2010dose photodynamic therapy PDT (photoinduction) can modulate tumor vessels and enhance the uptake of liposomal cisplatin (Lipoplatin\u00ae) in pleural malignancies. However, the photo\u2010induction conditions must be tightly controlled as overtreatment shuts down tumor vessels and enhances normal tissue drug uptake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In a pleural sarcoma and adenocarcinoma rat model (<jats:italic>n<\/jats:italic>\u2009=\u200912\/group), we applied photoinduction (0.0625\u2009mg\/kg Visudyne\u00ae, 10\u2009J\/cm<jats:sup>2<\/jats:sup>) followed by intravenous Lipoplatin\u00ae (5\u2009mg\/kg) administration. Tumor and normal tissue IFP were assessed before and up to 1\u2009hour following photoinduction. Lipoplatin\u00ae uptake was determined 60\u2009minutes following photoinduction. We then treated the pleura of tumor\u2010free minipigs with high dose photodynamic therapy (PDT) (0.0625\u2009mg\/kg Visudyne\u00ae, 30\u2009J\/cm<jats:sup>2<\/jats:sup>, <jats:italic>n<\/jats:italic>\u2009=\u20095) followed by Lipoplatin (5\u2009mg\/kg) administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In rodents, photoinduction resulted in a significant decrease of IFP (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in both tumor types but not in the surrounding normal lung, equally exposed to light. Also, photoinduction resulted in a significant increase of Lipoplatin\u00ae uptake in both tumor types (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) but not in normal lung. Tumor IFP variation and Lipoplatin\u00ae uptake fitted an inverted parabola. In minipigs, high dose photodynamic treatment resulted in pleural IFP increase of some animals which predicted higher Lipoplatin\u00ae uptake levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Normal and tumor vasculatures react differently to PDT. Continuous IFP monitoring in normal and tumor tissues is a promising biomarker of vessel photoinduction. Moderate drop in tumor with no change in normal tissue IFP are predictive of specific Lipoplatin\u00ae uptake by cancer following PDT. Lasers Surg. Med. 49:773\u2013780, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22687","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:02:42Z","timestamp":1495584162000},"page":"773-780","source":"Crossref","is-referenced-by-count":15,"title":["Interstitial fluid pressure: A novel biomarker to monitor photo\u2010induced drug uptake in tumor and normal tissues"],"prefix":"10.1002","volume":"49","author":[{"given":"Sabrina","family":"Cavin","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery Centre Hospitalier Universitaire Vaudois Lausanne Vaud Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Centre Hospitalier Universitaire Vaudois Lausanne Vaud 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