{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T18:35:37Z","timestamp":1788028537708,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to investigate the effect of two\u2010step irradiance schedule in relieving pain during PDT of CA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was a prospective, controlled trial of 141 CA patients who were randomly divided into Group A (two\u2010step irradiance schedule) and Group B (single\u2010dose cold compress). The numeric rating scales (NRS) of patients\u2019 pain were recorded at 5, 10, 15, and 20 minutes during each PDT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The efficacy of PDT and NRS scores of patients in the two groups were compared. There was no significant difference in gender, age, lesion site, and disease course between the two groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). In addition, the cure rate of patients in the two groups was not significantly different (97.1% vs. 95.8%, <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.000, <jats:italic>P<\/jats:italic>\u2009=\u20091.000). However, the NRS scores at different time points and number of PDT sessions were significantly different (<jats:italic>F<\/jats:italic>\u2009=\u2009198.233 and 165.224, respectively, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The NRS scores of patients in Group A were significantly lower than those of patients in Group B (<jats:italic>F<\/jats:italic>\u2009=\u200982.762, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Moreover, the NRS scores at different positions were significantly different (<jats:italic>F<\/jats:italic>\u2009=\u200928.286, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). The NRS scores of penis were significantly lower than those of the vulva and crissum (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with single\u2010dose cold compress, two\u2010step irradiance schedule could more significantly reduce the patients\u2019 pain degree during treatment, especially for vulva and crissum. Lasers Surg. Med. 49:908\u2013912, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22699","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T14:26:41Z","timestamp":1498141601000},"page":"908-912","source":"Crossref","is-referenced-by-count":16,"title":["Two\u2010step irradiance schedule versus single\u2010dose cold compress for pain control during 5\u2010aminolevulinic acid\u2010based photodynamic therapy of condyloma acuminatum"],"prefix":"10.1002","volume":"49","author":[{"given":"Xiaonan","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine The Third Affiliated Hospital of Soochow University Changzhou 213003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Third Affiliated Hospital of Soochow University Changzhou 213003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Third Affiliated Hospital of Soochow University Changzhou 213003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2014.12.032"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12043"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346330"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962012000400001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2010.12.011"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13547"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13788"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2011.00595.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22118"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2010.08.016"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.37.4.378"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-007-1363-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06211.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22243"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09437.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09583.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000106577"},{"issue":"7","key":"e_1_2_6_19_1","first-page":"825","article-title":"The efficacy of photodynamic therapy in actinic cheilitis of the lower lip: A prospective study of 15 patients","volume":"33","author":"Berking C","year":"2007","journal-title":"Dermatol Surg"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.11.060"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2010.12.008"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)03814-D"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000512"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22699","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.22699","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T13:00:14Z","timestamp":1695992414000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.22699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,22]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/lsm.22699"],"URL":"https:\/\/doi.org\/10.1002\/lsm.22699","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,22]]}}}