{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:18:20Z","timestamp":1790068700447,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Based on reports of poor wound healing and scarring, it is currently recommended that patients wait 6 months after completion of oral isotretinoin therapy before the safe initiation of laser treatment. Our aim was to evaluate the safety of non\u2010ablative fractional laser (NAFL) treatment for acne scars within 1 month after isotretinoin therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Methods<\/jats:title><jats:p>This was a randomized split\u2010face controlled trial involving 10 patients with acne scars who had completed isotretinoin treatment. All patients received three treatments each spaced 4 weeks apart with an erbium\u2010doped 1550\u2009nm NAFL on one side of the face within 1 month after isotretinoin therapy. The untreated side acted as a control. Wound healing and adverse effects as well as acne scar improvement were evaluated by two blinded dermatologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients demonstrated normal wound healing post NAFL treatments, and neither hypertrophic scars nor keloids were observed. Acne scar improvement was satisfactory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NAFL treatment for acne scarring appears to be well tolerated within 1 month of completing isotretinoin treatment. Dermatologists should reevaluate the current recommendation to wait 6 months after isotretinoin treatment for acne scar revision with lasers. Other larger studies are necessary to further challenge this dogma. Lasers Surg. Med. 49:886\u2013890, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22711","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T16:09:02Z","timestamp":1504022942000},"page":"886-890","source":"Crossref","is-referenced-by-count":25,"title":["Safety of non\u2010ablative fractional laser for acne scars within 1 month after treatment with oral isotretinoin: A randomized split\u2010face controlled trial"],"prefix":"10.1002","volume":"49","author":[{"given":"Sandeep S.","family":"Saluja","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Utah School of Medicine Salt Lake City Utah 84132"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Utah School of Medicine Salt Lake City Utah 84132"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika M.","family":"Summers","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Utah School of Medicine Salt Lake City Utah 84132"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payam","family":"Tristani\u2010Firouzi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Utah School of Medicine Salt Lake City Utah 84132"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Smart","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Utah School of Medicine Salt Lake City Utah 84132"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70167-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1988.tb02574.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70096-6"},{"key":"e_1_2_8_5_1","first-page":"228","article-title":"Keloid formation induced by isotretinoin therapy","volume":"38","author":"Ginarte M","year":"1999","journal-title":"Int J Dermatol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890370123029"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000185"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12544"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.768758"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22410"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22607"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33059.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34284.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30373.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32182.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170802612984"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000353"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.2077"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001019"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22711","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.22711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T13:00:31Z","timestamp":1695992431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.22711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,29]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/lsm.22711"],"URL":"https:\/\/doi.org\/10.1002\/lsm.22711","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,29]]}}}