{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:38:00Z","timestamp":1788201480948,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Syneron\/Candela"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Fractional treatment with a dual wavelength 1,064 and 532\u2009nm picosecond\u2010domain laser, delivering a 10\u2009\u00d7\u200910 array of highly focused beamlets <jats:italic>via<\/jats:italic> a holographic optic, was investigated for the treatment of acne scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study<\/jats:title><jats:p>Twenty\u2010seven of 31 subjects completed the study, 19 were treated using 1,064\u2009nm and 8 were treated at 532\u2009nm, all having four\u2010monthly treatments. Blinded evaluation of digital images by three physician evaluators comparing pre\u2010 and 3\u2010month post\u2010treatment images measured efficacy using a 10\u2010point scale. Subject self\u2010assessment of treatment effects were also recorded. Safety was measured by recording subject discomfort scores and adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Blinded reviewers correctly identified the baseline image in 61 of the 81 image sets (75%), and baseline acne scar scores were 1.8\u2009\u00b1\u20090.7 and 1.8\u2009\u00b1\u20090.5 for the 1,064 and 532\u2009nm cohorts, and decreased to 1.1\u2009\u00b1\u20090.5 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and 1.1\u2009\u00b1\u20090.0 (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.005), respectively. Post\u2010treatment erythema, mild edema, and petechiae were the only side effects noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 1,064 and 532\u2009nm picosecond\u2010domain laser incorporating a 10\u2009\u00d7\u200910 holographic beam\u2010splitting handpiece was found to be safe and effective for the treatment of facial acne scars. The treatments were well tolerated and the subjects experienced little to no downtime. Lasers Surg. Med. 49:796\u2013802, 2017. \u00a9 2017 The Authors. <jats:italic>Lasers in Surgery and Medicine<\/jats:italic> Published by Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22734","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T16:10:39Z","timestamp":1506615039000},"page":"796-802","source":"Crossref","is-referenced-by-count":66,"title":["Treatment of acne scarring with a novel fractionated, dual\u2010wavelength, picosecond\u2010domain laser incorporating a novel holographic beam\u2010splitter"],"prefix":"10.1002","volume":"49","author":[{"given":"Eric F.","family":"Bernstein","sequence":"first","affiliation":[{"name":"Main Line Center for Laser Surgery Ardmore Pennsylvania 19003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin T.","family":"Schomacker","sequence":"additional","affiliation":[{"name":"Syneron\u2010Candela Corporation 530 Boston Post Road Wayland Massachusetts 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