{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:43:19Z","timestamp":1778823799394,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T00:00:00Z","timestamp":1510617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Syneron-Candela Corp."},{"name":"Cynosure, Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Infraorbital dark circles result from a combination of factors. The fractionated picosecond 755\u2009nm alexandrite laser and dual wavelength picosecond Nd:YAG laser have not been examined as a method of addressing infraorbital hyperpigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the efficacy and safety of treatment of infraorbital dark circles using fractionated picosecond 755\u2009nm and dual wavelength picosecond Nd:YAG laser.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>These trials did not utilize a comparative design; rather, these were separate, prospective, open\u2010label, evaluator\u2010blinded trials utilizing two treatment regimens: (i) 19 adult subjects were treated in a single session with the dual wavelengths of 532\u2009nm and 1,064\u2009nm in consecutive passes using the fractionated lens; (ii) 10 adult subjects were treated using the picosecond 755\u2009nm laser via the fractionated lens in three treatment sessions at 3 week intervals. Subjects in both studies were followed\u2010up for blinded\u2010investigator assessment of infraorbital hyperpigmentation, adverse events, and improvement compared to baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The dual wavelength picosecond Nd:YAG laser, blinded\u2010investigator assessment did not demonstrate a significant improvement in infraorbital hyperpigmentation at day 60 (<jats:italic>P<\/jats:italic>\u2009=\u20090.16). The picosecond 755\u2009nm alexandrite laser significantly improved infraorbital hyperpigmentation by day 42, with improvement maintained through day 132 (<jats:italic>P<\/jats:italic>\u2009=\u20090.07 and 0.00001, respectively). Adverse events were mild and temporary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A single treatment with the fractionated picosecond 1,064\/532\u2009nm lasers did not produce a significant improvement in infraorbital hyperpigmentation. A series of three treatments with the fractionated picosecond 755\u2009nm laser resulted in significant improvement in hyperpigmentation. Lasers Surg. Med. 50:45\u201350, 2018. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22754","type":"journal-article","created":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T11:27:00Z","timestamp":1510658820000},"page":"45-50","source":"Crossref","is-referenced-by-count":28,"title":["Prospective studies of the efficacy and safety of the picosecond 755, 1,064, and 532\u2009nm lasers for the treatment of infraorbital dark circles"],"prefix":"10.1002","volume":"50","author":[{"given":"Monique J.","family":"Vanaman Wilson","sequence":"first","affiliation":[{"name":"California Skin Institute 603 S. Knickerbocker Drive Sunnyvale California 94087"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabela T.","family":"Jones","sequence":"additional","affiliation":[{"name":"McLean Dermatology and Skincare Center 6849 Old Dominion Drive Suite 340, McLean Virginia 22101"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Bolton","sequence":"additional","affiliation":[{"name":"Alliant Dermatology 8620 E. County Road 466 The Villages Florida 32162"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Larsen","sequence":"additional","affiliation":[{"name":"West Dermatology 4060 4th Ave, Suite 415 San Diego California 92103"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas C.","family":"Wu","sequence":"additional","affiliation":[{"name":"California Skin Institute 603 S. Knickerbocker Drive Sunnyvale California 94087"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchel P.","family":"Goldman","sequence":"additional","affiliation":[{"name":"California Skin Institute 603 S. Knickerbocker Drive Sunnyvale California 94087"},{"name":"Department of Dermatology, University of California San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2014.08.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1001\/archderm.1996.03890280047007","article-title":"Ultrapulse CO2 laser resurfacing of photoaged skin","volume":"132","author":"Fitzpatrick RE","year":"1996","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.08151.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.98159.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.10012"},{"key":"e_1_2_6_7_1","first-page":"e80","article-title":"Use of hyaluronic acid fillers to treat tear trough depression: a retrospective study of 2 techniques","volume":"11","author":"Hammon S","year":"2012","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22443"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22454"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000455"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22427"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000568"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000922"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001047"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.22754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T05:22:57Z","timestamp":1694582577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.22754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,14]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/lsm.22754"],"URL":"https:\/\/doi.org\/10.1002\/lsm.22754","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,14]]}}}