{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:42:38Z","timestamp":1791063758768,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T00:00:00Z","timestamp":1510531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Nevus of Ota represents congenital dermal melanocytosis in a trigeminal distribution, most commonly occurring in Asian individuals and other individuals with skin of color. Evidence suggests early treatment is beneficial. Multiple reports have shown efficacy and safety of Q\u2010switched laser treatment in adults. There is little data on children and in non\u2010Asian skin types. This series was done to demonstrate safe and effective use of Q\u2010switched laser therapy in children of multiple skin types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a chart review of patients under 18 years old who presented to our practice from 2002 to 2015 with a clinical diagnosis of nevus of Ota who were treated with Q\u2010switched lasers (694 and 1,064\u2009nm). Patients were treated without the use of general anesthesia or sedation, and corneal shields were used in appropriate cases. Percentage of improvement as well as side effects were rated by five physicians independently. Improvement, when present, was rated in quartiles (1\u201325%, 26\u201350%, 51\u201375%, and 76\u2013100% improvement).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four children were included. The average age at the start of treatment was 3.9 years old (range of 3 months to 12.4 years), and patients had Fitzpatrick skin types IV through VI. The mean number of treatments was 9.3. Assessment revealed excellent response (76\u2013100% improvement) in 70% of patients and good to excellent response (51\u2013100% improvement) in 86%. Two patients (8%) had post\u2010inflammatory hyperpigmentation, one of whom also had focal hypopigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment of nevus of Ota with Q\u2010switched lasers in children with skin of color, without general anesthesia or sedation, is safe and effective. Early intervention should be encouraged for better efficacy and to prevent psychosocial distress in later childhood and adulthood. Lasers Surg. Med. 50:56\u201360, 2018. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22757","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T09:13:04Z","timestamp":1510564384000},"page":"56-60","source":"Crossref","is-referenced-by-count":25,"title":["Successful and safe use of Q\u2010switched lasers in the treatment of nevus of Ota in children with phototypes IV\u2013VI"],"prefix":"10.1002","volume":"50","author":[{"given":"Daniel A.","family":"Belkin","sequence":"first","affiliation":[{"name":"Laser &amp; Skin Surgery Center of New York 317 East 34th Street New York New York 10016"},{"name":"Ronald O. Perelman Department of Dermatology New York University School of Medicine New York New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Jeon","sequence":"additional","affiliation":[{"name":"Laser &amp; Skin Surgery Center of New York 317 East 34th Street New York New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Weiss","sequence":"additional","affiliation":[{"name":"Laser &amp; Skin Surgery Center of New York 317 East 34th Street New York New York 10016"},{"name":"Department of Dermatology Weill Cornell Medical College New York New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A.","family":"Brauer","sequence":"additional","affiliation":[{"name":"Laser &amp; Skin Surgery Center of New York 317 East 34th Street New York New York 10016"},{"name":"Ronald O. Perelman Department of Dermatology New York University School of Medicine New York New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy G.","family":"Geronemus","sequence":"additional","affiliation":[{"name":"Laser &amp; Skin Surgery Center of New York 317 East 34th Street New York New York 10016"},{"name":"Ronald O. Perelman Department of Dermatology New York University School of Medicine New York New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1834-2"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33093.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1103"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.1996.11.2.165"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2000.00639.x"},{"issue":"8","key":"e_1_2_5_7_1","first-page":"639","article-title":"Treatment of Ota's nevus by Q\u2010switched alexandrite laser: therapeutic outcome in relation to clinical and histopathological findings","volume":"9","author":"Kang W","year":"1999","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412293312604"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1992.04530010056008"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1995.tb00512.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2010.05.036"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.026010919.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.0260111000.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq302"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001003"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.10171"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000212"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20788"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1999)24:1<24::AID-LSM5>3.0.CO;2-Z"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20529"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12526"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22454"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22443"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000326"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22757","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.22757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T05:23:00Z","timestamp":1694582580000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.22757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,13]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/lsm.22757"],"URL":"https:\/\/doi.org\/10.1002\/lsm.22757","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,13]]}}}