{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:45:32Z","timestamp":1789159532403,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effects of laser monotherapy on quality of life in breast cancer patients with chronic radiation dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A prospective, IRB\u2010approved study was conducted at Memorial Sloan Kettering Cancer Center. Breast cancer patients with chronic radiation dermatitis completed health\u2010related quality of life (HR\u2010QOL) questionnaires before and after laser monotherapy for radiation\u2010induced breast telangiectasias (RIBT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After informed consent, all patients were issued the Skindex\u201016 and Breast\u2010Q Adverse Effects of Radiation HR\u2010QOL questionnaires prior to receiving laser treatment. Patients were treated with a 595\u2009nm pulsed dye laser at 4\u2010 to 6\u2010week intervals, with percent telangiectasia clearance and adverse events recorded at each visit. Post\u2010treatment HR\u2010QOL questionnaires were collected after clinician\u2010assessed telangiectasia clearance of &gt;50%. Median HR\u2010QOL scores before and after therapy were reported for individual HR\u2010QOL domains (Skindex\u201016) and HR\u2010QOL totals (Skindex\u201016 and Breast\u2010Q Adverse Effects of Radiation). Before\u2010 and after\u2010differences were calculated using the Wilcoxon Signed\u2010Rank Test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two female patients (average age 56 years) enrolled in this study. A majority (13\/22, 59%) exhibited telangiectasias across the d\u00e9colletage and axilla in addition to the breast. Sixteen patients reached the 50% RIBT clearance threshold during the study period, and 11 of these patients (69%) completed follow\u2010up HR\u2010QOL questionnaires. Patients showed statistically significant improvements in emotional and functional Skindex\u201016 HR\u2010QOL domains and in overall Skindex\u201016 HR\u2010QOL score. Breast\u2010Q scores also improved significantly, illustrating a decrease in specific physical and cosmetic concerns common to radiated breast skin. Common adverse events were transient post\u2010treatment pain and redness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Breast cancer patients with RIBT presented with substantial deficits in several HR\u2010QOL arenas. Laser monotherapy effectively treated the appearance of radiation dermatitis in these patients and also significantly improved HR\u2010QOL. Lasers Surg. Med. 50:284\u2013290, 2018. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22780","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T09:03:10Z","timestamp":1513760590000},"page":"284-290","source":"Crossref","is-referenced-by-count":18,"title":["Effect of laser therapy on quality of life in patients with radiation\u2010induced breast telangiectasias"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2295-1934","authenticated-orcid":false,"given":"Anthony M.","family":"Rossi","sequence":"first","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center 16 East 60th St. 4th Floor New York 10022 New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina R.","family":"Blank","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center 16 East 60th St. 4th Floor New York 10022 New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishwer","family":"Nehal","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center 16 East 60th St. 4th Floor New York 10022 New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Dusza","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center 16 East 60th St. 4th Floor New York 10022 New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center 16 East 60th St. 4th Floor New York 10022 New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S94320"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-006-9480-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.08.021"},{"issue":"12","key":"e_1_2_7_6_1","first-page":"34","article-title":"Radiation\u2010induced breast telangiectasias treated with the pulsed dye laser","volume":"7","author":"Rossi AM","year":"2014","journal-title":"J Clin Aesthet Dermatol"},{"issue":"3","key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1054\/bjps.1998.3041","article-title":"Pulsed dye laser treatment of telangiectasia after radiotherapy for breast carcinoma","volume":"52","author":"Ahmad M","year":"1999","journal-title":"Br J Plast Surg"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2011.11.003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12365600"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31823aec6b"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2017.02.015"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09104.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906260"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2017.02.012"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22548"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22436"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22532"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22780","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.22780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:54:45Z","timestamp":1695560085000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.22780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,20]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/lsm.22780"],"URL":"https:\/\/doi.org\/10.1002\/lsm.22780","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,20]]}}}