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Subjects were enrolled and OCTA imaging was performed with a field of view of approximately 10\u2009\u00d7\u200910\u2009mm. Skin blood flow was identified using an optical microangiography (OMAG) algorithm. Depth\u2010resolved microvascular networks and structural features were derived from segmented volume scans, representing tissue slabs of 0\u2013132, 132\u2013330, and 330\u2013924\u2009\u03bcm, measured from the surface of the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subjects with both healthy and pathological conditions, such as benign skin lesions, psoriasis, chronic graft\u2010versus\u2010host\u2010disease (cGvHD), and scleroderma, were OCTA scanned. Our OCTA results detailed variations in vascularization and local anatomical characteristics, for example, depth\u2010dependent vascular, and structural alterations in psoriatic skin, alongside their resolve over time; vascular density changes and distribution irregularities, together with corresponding structural depositions in the skin of cGvHD patients; and vascular abnormalities in the nail folds of a patient with scleroderma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OCTA can image capillary blood flow and structural features within skin <jats:italic>in vivo<\/jats:italic>, which has the potential to provide new insights into the pathophysiology, as well as dynamic changes of skin diseases, valuable for diagnoses, and non\u2010invasive monitoring of disease progression and treatment. Lasers Surg. 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