{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:29:14Z","timestamp":1791322154747,"version":"4.3.1"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["16K11790"],"award-info":[{"award-number":["16K11790"]}]},{"name":"JSPS KAKENHI","award":["16K20644"],"award-info":[{"award-number":["16K20644"]}]},{"name":"JSPS KAKENHI","award":["25862016"],"award-info":[{"award-number":["25862016"]}]},{"name":"JSPS KAKENHI","award":["17K17327"],"award-info":[{"award-number":["17K17327"]}]},{"name":"JSPS KAKENHI","award":["15K20595"],"award-info":[{"award-number":["15K20595"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Tooth movement during orthodontic treatment is associated with bone neoplasticity and bone resorption on the tension and pressure sides. Previous clinical studies have suggested that low\u2010power laser irradiation can accelerate tooth movement during orthodontic treatment, although the underlying mechanism remains unclear. In this study, we used a high\u2010frequency near\u2010infrared diode laser that generates less heat and examined the histologic changes in periodontal tissue during experimental tooth movement with laser irradiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nickel\u2010titanium closed coil was mounted between the maxillary left side first molar and incisor of rats to model experimental tooth movement. The laser\u2010irradiation and the control groups were set, and the amount of movement of the first molar on 7th and 14th days after the start of pulling of the first molar tooth on the maxillary left was measured by three\u2010dimensional analysis of \u00b5CT. After tooth movement, tissue samples from the mesial and tension sides were collected, and successive horizontal sections were prepared and examined using hematoxylin\u2013eosin and TRAP staining and immunohistochemical staining for RANKL, OPG, ALP, and proliferating cell nuclear antigen (PCNA). Changes in tissue temperature following laser irradiation were also examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Laser irradiation significantly increased tooth movement compared with non\u2010irradiated controls. Histologic staining of the pressure\u2010side mesial root in laser\u2010irradiated rats revealed enhanced RANKL expression and increased numbers of TRAP\u2010positive cells compared with controls. By contrast, on the tension side, laser irradiation led to increased expression of ALP and PCNA. These data indicate that high\u2010frequency near\u2010infrared diode laser irradiation on the pressure side upregulates RANKL expression and accelerates osteoclast differentiation, facilitating bone resorption, whereas bone formation is induced on the tension side.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that high\u2010frequency near\u2010infrared diode laser irradiation of periodontal tissue leads to metabolic activation, which ultimately increases the rate of tooth movement. Lasers Surg. Med. 50:772\u2013780, 2018. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22797","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T09:38:39Z","timestamp":1517823519000},"page":"772-780","source":"Crossref","is-referenced-by-count":19,"title":["Effect of high\u2010frequency near\u2010infrared diode laser irradiation on periodontal tissues during experimental tooth movement in rats"],"prefix":"10.1002","volume":"50","author":[{"given":"Hidemi","family":"Gunji","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Craniofacial Developmental Biology Hiroshima University Graduate School of Biomedical Sciences 1\u20102\u20103 Kasumi, Minami\u2010ku Hiroshima 734\u20108553 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Kunimatsu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Craniofacial Developmental Biology Hiroshima University 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