{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:49:18Z","timestamp":1790005758764,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T00:00:00Z","timestamp":1518220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002602","name":"American Society for Laser Medicine and Surgery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Acute radiodermatitis (RD) is a distressing and painful skin reaction that occurs in 95% of the patients undergoing radiotherapy (RT). The aim of this study was to evaluate the effectiveness of photobiomodulation therapy (PBMT) in the prevention of acute RD in breast cancer (BC) patients undergoing RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a randomized, placebo\u2010controlled trial including 120 BC patients that underwent an identical RT regimen post\u2010lumpectomy. Patients were randomly assigned to the laser therapy (LT) or placebo group, with 60 patients in each group. Laser or placebo treatments were applied 2 days a week, immediately after the RT session, starting at the first day of RT. PBMT was delivered using a class IV MLS<jats:sup>\u00ae<\/jats:sup> M6 laser that combines two synchronized laser diodes in the infrared range (808\u2013905\u2009nm) with a fixed energy density (4\u2009J\/cm<jats:sup>2<\/jats:sup>). Skin reactions were scored based on the criteria of the Radiation Therapy Oncology Group (RTOG) and the Radiation\u2010Induced Skin Reaction Assessment Scale (RISRAS). The patients completed the Skindex\u201016 questionnaire to evaluate their quality of life. All the measurements were collected at the first day, at a RT dose of 40 Gray (Gy), and at the end of RT (total dose 66\u2009Gy).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a RT dose of 40\u2009Gy, there was no significant difference between the groups in the distribution of RTOG grades. However, at the end of RT the severity of the skin reactions significantly differed between the two groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.004), with a larger percentage of patients experiencing RTOG grade 2 or higher (e.g., moist desquamation) in the placebo group (30% vs. 6.7%, for the placebo and laser group, resp.). The objective RISRAS score confirmed these results. In addition, the Skindex\u201016 and RISRAS subjective score demonstrated that the patients\u2019 quality of life was significantly better in the LT than in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this trial show that PBMT is an effective tool to prevent the development of grade 2 acute RD or higher in BC patients. In addition, it also reduces the patients\u2019 symptoms related to RD. Lasers Surg. Med. 50:763\u2013771, 2018. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22804","type":"journal-article","created":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T07:02:35Z","timestamp":1518246155000},"page":"763-771","source":"Crossref","is-referenced-by-count":55,"title":["Prevention of acute radiodermatitis by photobiomodulation: A randomized, placebo\u2010controlled trial in breast cancer patients (TRANSDERMIS trial)"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6286-1581","authenticated-orcid":false,"given":"Jolien","family":"Robijns","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Life Sciences Hasselt University Martelarenlaan 42, 3500 Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Censabella","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jessa Hospital Stadsomvaart 11, 3500 Hasselt 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