{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:51Z","timestamp":1786978131071,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Syneron-Candela"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The pulsed\u2010dye laser has been used to treat facial redness and rosacea for decades. Recent advances in dye laser technology enable 50% higher output energies supporting 50% larger treatment areas, and beam\u2010diameters up to 15\u2009mm with clinically\u2010relevant fluences. In this study, we investigate this novel pulsed\u2010dye laser using a 15\u2009mm diameter beam for treatment of rosacea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty subjects with erythemato\u2010telangiectatic rosacea were enrolled in the study. A total of 4 monthly treatments were administered, first treating linear vessels with a 3\u2009\u00d7\u200910\u2009mm elliptical beam, then diffuse redness with a 15\u2010mm diameter circular beam. Blinded assessment of digital, cross\u2010polarized photographs taken 2 months following the last treatment was performed using an 11\u2010point clearance scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nineteen subjects completed the study. Blinded reviewers correctly identified baseline photos in 55 out of the total of 57 images (96.5%). The blinded reviewers scored 17 of the 19 subjects with an improvement greater than 40%, and 11 of the 19 subjects greater than 50%. The average improvement was 53.9%. Side effects were limited to mild edema, mild to moderate erythema, and mild to moderate bruising.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study demonstrates that a newly designed pulsed\u2010dye laser having a novel 15\u2010mm diameter treatment beam improves the appearance of rosacea with a favorable safety profile. Lasers Surg. Med. 50:808\u2013812, 2018. \u00a9 2018 The Authors.\n                      <jats:italic>Lasers in Surgery and Medicine<\/jats:italic>\n                      Published by Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.22819","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T19:45:33Z","timestamp":1523389533000},"page":"808-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Pulsed dye laser treatment of rosacea using a novel 15\u2009mm diameter treatment beam"],"prefix":"10.1002","volume":"50","author":[{"given":"Eric F.","family":"Bernstein","sequence":"first","affiliation":[{"name":"Mainline Center for Laser Surgery Ardmore Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Schomacker","sequence":"additional","affiliation":[{"name":"Syneron\u2010Candela Corporation Wayland Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Paranjape","sequence":"additional","affiliation":[{"name":"Syneron\u2010Candela Corporation Wayland Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Jones","sequence":"additional","affiliation":[{"name":"Syneron\u2010Candela Corporation Wayland Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.08.028"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.04.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp042829"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.1998.tb00003.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/44\/4\/008"},{"key":"e_1_2_6_8_1","unstructured":"Rosacea now estimated to affect at least 16 million Americans. Rosacea Review 2010;http:\/\/www.rosacea.org\/rr\/2010\/winter\/article_1.php Accessed November 26 2017."},{"issue":"5","key":"e_1_2_6_9_1","first-page":"419","article-title":"An epidemiological study of rosacea","volume":"69","author":"Berg M","year":"1989","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20621"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900110616"},{"key":"e_1_2_6_12_1","first-page":"1437","article-title":"Role of beam spot size in heating targets at depth","volume":"14","author":"Ross EV","year":"2015","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2317-4"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.22819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T04:09:21Z","timestamp":1695010161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.22819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,10]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/lsm.22819"],"URL":"https:\/\/doi.org\/10.1002\/lsm.22819","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,10]]},"assertion":[{"value":"2018-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}