{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:50:27Z","timestamp":1787068227976,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571902"],"award-info":[{"award-number":["81571902"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI050875"],"award-info":[{"award-number":["R01AI050875"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI121700"],"award-info":[{"award-number":["R21AI121700"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007055","name":"Third Military Medical University","doi-asserted-by":"publisher","award":["SWH2014LC17"],"award-info":[{"award-number":["SWH2014LC17"]}],"id":[{"id":"10.13039\/501100007055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acne scarring is a common disfiguring sequela of acne vulgaris which can lead to serious psychosocial problems and have a negative effect on patients\u2019 quality of life. Although a variety of approaches can be used to treat atrophic acne scars, disadvantages such as long\u2010healing time, dyspigmentation, infections, and prolonged erythema make these treatments unsatisfactory especially for Asians. Fractional micro\u2010plasma radio\u2010frequency is a novel technology that produces minor ablation to the epidermis to promote rapid re\u2010epithelialization, while the radio\u2010frequency evoked thermal effect can stimulate regeneration and remodeling of dermal fibroblasts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the clinical effectiveness and safety of micro\u2010plasma radio\u2010frequency for the treatment of facial acne scars in Chinese patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A total of 95 patients with facial atrophic acne scars were treated by micro\u2010plasma radio\u2010frequency using three sessions at 2\u2010month intervals. Patients were seen 1 week after each treatment and 1, 3, 6 months after the final treatment. Improvement was assessed by three independent dermatologists who compared photographs taken before the first treatment and 6 months after the last treatment. Adverse effects were evaluated by a dermatologist who did not participated in the study. Patients also provided self\u2010evaluation of satisfaction levels at the last follow\u2010up visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 86 patients with atrophic acne scars completed the entire study. There was a significant improvement in acne scars after three treatments. The mean score of ECCA grading scale (Echelle d'Evaluation Clinique des Cicatrices d'Acn\u00e9) was reduced from 107.21 to 42.27 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). A total of 15 of 86 patients showed more than 75% improvement, 57 patients showed 50\u201375% improvement, and 14 patients showed 25\u201350%. After three treatments, all subjects showed improvements in spots, large pores, texture, UV damage, red areas, and porphyrin fluorescence. Pain, erythema, edema, effusion, and scab formation were observed in all patients. The average pain score on a visual analog scale was 6.14\u2009\u00b1\u20091.12 and all patients tolerated the treatments. The average duration of erythema was 6.26\u2009\u00b1\u20090.92 days. Hyperpigmentation, hypopigmentation, infections, and worsening of scarring were not seen. All patients were either \u201cvery satisfied\u201d or \u201csatisfied\u201d with the treatment outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fractional micro\u2010plasma radio\u2010frequency is an effective and safe treatment for acne scars, and might be a good choice for patients with darker skin. Lasers Surg. Med. 50:844\u2013850, 2018. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.22825","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T23:52:11Z","timestamp":1523922731000},"page":"844-850","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Treatment of atrophic acne scarring with fractional micro\u2010plasma radio\u2010frequency in Chinese patients: A prospective study"],"prefix":"10.1002","volume":"50","author":[{"given":"Ting","family":"Lan","sequence":"first","affiliation":[{"name":"Department of Dermatology, Southwest Hospital Third Military Medical University Chongqing 400038 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Southwest Hospital Third Military Medical University Chongqing 400038 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