{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:28:33Z","timestamp":1790634513826,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Genitourinary syndrome of menopause (GSM) combines the conditions of vulvovaginal atrophy (VVA) and urinary tract dysfunction, which is a result of urethral atrophy. There are several treatment methods available for the management of vulvovaginal symptoms of GSM, whereas urinary tract dysfunction often remains overlooked and undertreated. The objective of this pilot study was to assess the safety and efficacy of intraurethral Er:YAG laser treatment of urinary symptoms of GSM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Patients with diagnosed GSM, having less than 5% of vaginal superficial cells in the cytology, vaginal pH higher than 5, with urinary symptoms of GSM (dysuria, frequency, urgency) and impaired continence due to urethral atrophy, received two sessions of intraurethral Er:YAG laser with a 3\u2010week interval in\u2010between the sessions. Laser energy was delivered in non\u2010ablative way using Erbium SMOOTH\u2122 mode technology and a 4\u2010mm thick cannula. Therapeutic efficacy was determined using ICIQ\u2010SF, the 1\u2010hour pad test and VAS scores. Occurrence of adverse effects was followed at every visit. Follow ups (FU) were at 3 and 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>29 female patients fulfilling the inclusion criteria were included in this pilot study and received two sessions of the intraurethral non\u2010ablative Erbium SMOOTH\u2122 laser therapy. Significant improvement was observed in all measured parameters at both FU. ICIQ\u2010SF improved by an average of 64% at 3 months FU and by 40% at 6 months. The 1\u2010hour pad test showed a reduction of the quantity of leaked urine by 59% at 3 months FU and by 42% at 6 months FU. All urinary symptoms of GSM improved. Dysuria dropped to 13% and 31% of baseline values at three and 6 months respectively, urinary urgency dropped to 23% and 47% and frequency dropped to 22% and 43% after 3 and 6 months, respectively. Adverse effects were mild and transient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that intraurethral Er:YAG laser is an efficacious and safe modality for treatment of urinary symptoms of GSM, however, prospective, randomized, and controlled trials with larger number of patients are needed to better assess the long\u2010term effect of this novel procedure. Lasers Surg. Med. 50:802\u2013807, 2018. \u00a9 2018 The Authors. <jats:italic>Lasers in Surgery and Medicine<\/jats:italic> Published by Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22826","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T10:23:57Z","timestamp":1524047037000},"page":"802-807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Intraurethral Erbium:YAG laser for the management of urinary symptoms of genitourinary syndrome of menopause: A pilot study"],"prefix":"10.1002","volume":"50","author":[{"given":"Adrian","family":"Gaspar","sequence":"first","affiliation":[{"name":"Espacio Gaspar Clinic Olascoaga 881 5500 Mendoza Argentina"},{"name":"Uroclinica Mendoza Paso de Los Andes 5500 Mendoza Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Maestri","sequence":"additional","affiliation":[{"name":"Espacio Gaspar Clinic Olascoaga 881 5500 Mendoza Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Silva","sequence":"additional","affiliation":[{"name":"Uroclinica Mendoza Paso de Los Andes 5500 Mendoza Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Brandi","sequence":"additional","affiliation":[{"name":"Espacio Gaspar Clinic Olascoaga 881 5500 Mendoza Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Luque","sequence":"additional","affiliation":[{"name":"Espacio Gaspar Clinic Olascoaga 881 5500 Mendoza Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ne\u017ea","family":"Koron","sequence":"additional","affiliation":[{"name":"Fotona d.o.o. 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