{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:44:39Z","timestamp":1780393479242,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the long\u2010term effectiveness of LASER treatment in women affected by high\u2010grade vaginal intra\u2010epithelial neoplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of consecutive women treated for high\u2010grade vaginal intra\u2010epithelial neoplasia were retrieved. Efficacy and long\u2010term effectiveness of ablative and excisional procedures were tested using a propensity\u2010matched algorithm. Risk of recurrence over the time was assessed using Kaplan\u2013Meier and Cox models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 204 patients met the inclusion criteria. LASER ablation and exicision were performed in 169 (82.8%) and 35 (17.2%) patients. A total of 41 (20%) patients developed high\u2010grade vaginal intraepithelial neoplasia at a median follow\u2010up of 65 (range, 6\u2013120) months. We observed that only HPV persistence (HR: 2.37 [95%CI:1.03, 5.42]; <jats:italic>P<\/jats:italic>\u2009=\u20090.04) was associated with the risk of recurrence at multivariate analysis. Seven (3.4%) invasive cancers of the lower genital tract were observed in our population. Considering the efficacy of type of procedure (after we applied the propensity\u2010matched analysis), we observed that type of procedure did not influence persistence of HPV infection (22.8% after excision and 15.7% after ablation; <jats:italic>P<\/jats:italic>\u2009=\u20090.424). Similarly, recurrence (17.1% vs. 18.6%; <jats:italic>P<\/jats:italic>\u2009=\u20091.00) and lower genital tract (2.8% vs. 1.4%; <jats:italic>P<\/jats:italic>\u2009=\u20091.00) rates were similar between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women affected by high\u2010grade vaginal intra\u2010epithelial neoplasia are at high risk of recurrence. LASER ablation seems to be equivalent to excision in term of long\u2010term effectiveness. Lasers Surg. Med. 50:933\u2013939, 2018. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22941","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T09:32:33Z","timestamp":1526290353000},"page":"933-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["LASER treatment for women with high\u2010grade vaginal intraepithelial neoplasia: A propensity\u2010matched analysis on the efficacy of ablative versus excisional procedures"],"prefix":"10.1002","volume":"50","author":[{"given":"Giorgio","family":"Bogani","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology IRCCS National Cancer Institute Milan 20133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Ditto","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology IRCCS National Cancer Institute Milan 20133 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Roberti Maggiore","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology IRCCS National Cancer Institute Milan 20133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Sabatucci","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology IRCCS National Cancer Institute Milan 20133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"Lorusso","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology IRCCS National Cancer Institute Milan 20133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Raspagliesi","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology IRCCS National Cancer Institute Milan 20133 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