{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T21:25:10Z","timestamp":1769721910805,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,17]],"date-time":"2018-06-17T00:00:00Z","timestamp":1529193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Laser and intense pulsed light (IPL) are standard symptomatic treatments for superficial telangiectasias, but postoperative erythema, oedema, and pain may prolong downtime.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether topical brimonidine reduces IPL\u2010induced inflammation in patients with moderate to severe facial telangiectasias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, two\u2010centre, single\u2010blinded, split\u2010face trial on adjuvant brimonidine and air\u2010cooling versus air\u2010cooling alone (control) in 19 patients treated in Denmark (<jats:italic>n<\/jats:italic>\u2009=\u200910 patients) and Belgium (<jats:italic>n<\/jats:italic>\u2009=\u20099). Brimonidine was applied to the allocated side after each of three facial IPL\u2010treatments, given at 3\u2010week intervals. Patients were assessed up to 1 month after the final treatment. Outcome measures included blinded clinical on\u2010site evaluation of erythema and oedema (5\u2010point\u2010scales), objective erythema\u2010scores (red\u2010filter analysis), patient\u2010evaluated pain (Visual Analogue Scale), IPL\u2010efficacy (blinded photo\u2010evaluation of telangiectasia clearance), and patient preference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 19 patients were enrolled and completed the study. IPL induced moderate to severe erythema after each treatment. Application of brimonidine, reduced erythema to baseline values compared to air\u2010cooling alone and sustained efficacy 24 hours after treatment (median difference reduction: score 1 at each assessment, <jats:italic>P<\/jats:italic>\u2009\u2264\u20090.022). Objective erythema\u2010scores supported clinical findings, demonstrating a median erythema reduction of 50\u201395% after application of brimonidine and air\u2010cooling compared to 9\u201328% reduction after air\u2010cooling alone (<jats:italic>P<\/jats:italic>\u2009\u2265\u20090.002). No difference in reduction of IPL\u2010induced oedema was observed between facial sides (<jats:italic>P<\/jats:italic>\u2009\u2265\u20090.227). Brimonidine and air\u2010cooling slightly and consistently reduced postoperative pain compared to air\u2010cooling alone (VAS 1.0 after brimonidine versus VAS 1.5\u20132.0 after air\u2010cooling alone at treatment 1\u20133, <jats:italic>P<\/jats:italic>\u2009\u2264\u20090.032). At 1\u2010month follow\u2010up, patients experienced excellent clearance of telangiectasias (75\u2013100% clearance) on both facial sides (<jats:italic>P<\/jats:italic>\u2009<jats:italic>=\u2009<\/jats:italic>1.000). Patient preference supported clinical data and 79% of patients preferred brimonidine to control (<jats:italic>P<\/jats:italic>\u2009=\u20090.019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared to air\u2010cooling alone, adjuvant brimonidine reduces IPL\u2010induced erythema and associated pain while maintaining a high IPL\u2010efficacy. Lasers Surg. Med. 50:1002\u20131009, 2018. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22953","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T04:50:01Z","timestamp":1529297401000},"page":"1002-1009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Topical brimonidine reduces IPL\u2010induced erythema without affecting efficacy: A randomized controlled trial in patients with facial telangiectasias"],"prefix":"10.1002","volume":"50","author":[{"given":"Anne\u2010Cathrine E.","family":"Vissing","sequence":"first","affiliation":[{"name":"Department of Dermatology Bispebjerg University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Dierickx","sequence":"additional","affiliation":[{"name":"Skinperium Clinic Boom Beukenlaan 52 2850 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrine E.","family":"Karmisholt","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merete","family":"Haedersdal","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20811"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70187-X"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13177"},{"key":"e_1_2_6_5_1","first-page":"37","article-title":"Successful treatment of erythematotelangiectatic rosacea with pulsed light and 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