{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:04:45Z","timestamp":1773720285169,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T00:00:00Z","timestamp":1530576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Sentinel diagnostic in cervical cancer is performed using Technetium\u201099m\u2010nanocolloid as a radioactive marker with or without patent blue. In the last years, indocyanine green has been evaluated for sentinel diagnostic in different tumor entities. Indocyanine green is a fluorescent molecule which emits a light signal in the near infrared band after excitation. Our study aims to evaluate indocyanine green compared to the gold standard Tc\u201099m\u2010nanocolloid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We included patients with early cervical cancer up to FIGO stage IIA with clinically node\u2010negative pelvic sites and the indication for nodal staging in this prospective trial. Sentinel diagnostic was carried out using Tc\u201099m\u2010nanocolloid, indocyanine green and patent blue. We examined each pelvic site for light signals from the near infrared band, for radioactivity and for blue staining. A sentinel lymph node was defined as a Tc\u201099m\u2010nanocolloid positive lymph node. All sentinel lymph nodes and all additional blue or fluorescent lymph nodes were excised and tested; then sent to histologic examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010three patients were included in which we found 211 Tc\u201099m\u2010nanocolloid\u2010positive sentinel lymph nodes in 66 pelvic sites. Two hundred and seven of these lymph nodes were positive for indocyanine green, too, giving a sensitivity of 98.1% (95%CI 94.9\u201399.4%) compared to Tc\u201099m\u2010nanocolloid. One hundred and sixty additional lymph nodes showed indocyanine green fluorescence but no Tc\u201099m\u2010positivity, so that the sensitivity was 79.6% (95%CI 76.6\u201382.3%). In one patient, a pelvic site was only identified to be tumor infiltrated due to an ICG\u2010positive, but Tc\u201099m\u2010negative lymph node.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results show that indocyanine green is a promising approach for pelvic sentinel identification in cervical cancer. ICG has a similar sensitivity as radioactive Tc\u201099m\u2010nanocolloid and may enhance both patient safety and surgeons\u2019 comfort. Lasers Surg. Med. 50:994\u20131001, 2018. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22999","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T13:28:42Z","timestamp":1530624522000},"page":"994-1001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Sentinel lymphadenectomy in cervical cancer using near infrared fluorescence from indocyanine green combined with technetium\u201099m\u2010nanocolloid"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5743-5505","authenticated-orcid":false,"given":"Philipp","family":"Soergel","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Kirschke","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0117-4366","authenticated-orcid":false,"given":"R\u00fcdiger","family":"Klapdor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Derlin","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hillemanns","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Hertel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.01.026"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00354.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(90)90072-S"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.8933"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.0432"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.08.337"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.09.010"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000032"},{"issue":"44","key":"e_1_2_6_10_1","first-page":"pii: 2225","article-title":"Multispectral real\u2010time fluorescence imaging for intraoperative detection of the sentinel lymph node in gynecologic oncology","author":"Crane LM","year":"2010","journal-title":"J Vis Exp"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.07.002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000996"},{"key":"e_1_2_6_13_1","article-title":"Sentinel lymphonodectomy in early vaginal cancer using combined near infrared fluorescence from indocyanine green and technetium\u201099m nanocolloid\u2014A first case report","volume":"3","author":"Soergel P","year":"2017","journal-title":"Clin Obstet Gynecol Reprod Med"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2310\/7290.2009.00031"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-5022-1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2015.09.022"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2017.09.004"},{"key":"e_1_2_6_18_1","unstructured":"Guidelines program oncology (German Cancer Society German Cancer Aid): S3\u2010Guideline Diagnosis therapy and follow\u2010up of the patient with cervical version. 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