{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:23:59Z","timestamp":1790742239790,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:00:00Z","timestamp":1537142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007299","name":"Harvard Catalyst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007299","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001102"],"award-info":[{"award-number":["UL1 TR001102"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Transcranial photobiomodulation (t\u2010PBM) consists of the delivery of near\u2010infrared (NIR) or red light to the scalp designed to penetrate to subjacent cortical areas of the brain. NIR t\u2010PBM has recently emerged as a potential therapy for brain disorders. This study assessed the efficacy of repeated sessions of NIR t\u2010PBM on sexual dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a secondary analysis of a double\u2010blind clinical trial on t\u2010PBM for major depressive disorder (MDD). Twenty individuals received NIR t\u2010PBM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099) or sham therapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911) twice a week for 8 weeks. Sexual desire, arousal, and orgasm were assessed using the Systematic Assessment for Treatment\u2010Emergent Effects\u2010Specific Inquiry (SAFTEE\u2010SI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean improvement in sexual function (decrease in SAFTEE sex total score) in subjects receiving t\u2010PBM in NIR\u2010mode was significantly greater than in subjects receiving sham\u2010mode in the whole sample (NIR [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099] \u22122.55\u2009\u00b1\u20091.88 vs. sham [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911] \u22120.45\u2009\u00b1\u20091.21;\n                      <jats:italic>z<\/jats:italic>\n                      \u2009=\u20092.548,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.011]) and in the completers (NIR [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095] \u22123.4\u2009\u00b1\u20091.95 vs. sham [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097] \u22120.14\u2009\u00b1\u20091.21;\n                      <jats:italic>z<\/jats:italic>\n                      \u2009=\u20092.576,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.010]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This exploratory study with a small sample size indicates that repeated sessions of NIR t\u2010PBM may be associated with therapeutic effects on sexual dysfunction. The latter appeared unrelated to the antidepressant effect of t\u2010PBM in our cohort. Lasers Surg. Med. 51:127\u2013135, 2019. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.23011","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T05:51:15Z","timestamp":1537163475000},"page":"127-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Effects of transcranial photobiomodulation with near\u2010infrared light on sexual dysfunction"],"prefix":"10.1002","volume":"51","author":[{"given":"Paolo","family":"Cassano","sequence":"first","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Dording","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Boston 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