{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:31:02Z","timestamp":1789173062017,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T00:00:00Z","timestamp":1535414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The picosecond alexandrite laser with diffractive lens array (DLA) offers the dual advantages of a picosecond pulse duration and the fractionated delivery of laser energy. This study explores the efficacy and safety of the DLA for treatment of multiple aesthetic concerns associated with photoaging of the face including skin texture irregularities, dyspigmentation, enlarged pore size, rhytides, and skin laxity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, evaluator\u2010blinded trial enrolled Fitzpatrick skin type III\u2013IV patients with mild to moderate signs of facial photoaging. Patients received six full face treatments at 4 week intervals for a total of 107 treatments. Standardized photography was obtained at baseline and at 1, 2, and 3 month follow\u2010up visits. Two independent blinded evaluators rated each of the five signs of photoaging on a 10\u2010point visual analog scale (VAS) at each follow\u2010up visit compared to baseline. A global aesthetic improvement score was also assigned at each follow\u2010up visit. Secondary outcomes included patient\u2010rated pain and heat sensation on a 10\u2010point VAS, and overall satisfaction. Adverse events were noted after each treatment and at each follow\u2010up visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 18 Chinese patients age 35\u201359 completed the study. A statistically significant improvement in skin texture and dyspigmentation scores was noted at the 1 month follow\u2010up that was sustained at 3 months. No significant improvements wer\u00ad\u00ade observed in pore size, rhytides, or skin laxity. The mean pain score was 5.1\u2009\u00b1\u20092 and mean heat sensation was 3.6\u2009\u00b1\u20092.1. Expected transient erythema and edema occurred in 95.3% (102\/107) and 1.9% (2\/108) of treatments, respectively, and resolved in hours. No incidences of post\u2010inflammatory hyperpigmentation (PIH) were noted at the 1, 2, and 3 month visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 755\u2010nm picosecond laser with DLA is a safe and effective non\u2010ablative modality for targeting facial skin texture irregularities and dyspigmentation in Chinese skin. Patients tolerated the treatment well with adverse effects limited to transient erythema and edema. Lasers Surg. Med. 51:8\u201313, 2019. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23014","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T02:10:11Z","timestamp":1535595011000},"page":"8-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Efficacy and safety of picosecond 755\u2010nm alexandrite laser with diffractive lens array for non\u2010ablative rejuvenation in Chinese skin"],"prefix":"10.1002","volume":"51","author":[{"given":"Heidi","family":"Wat","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Yee\u2010nam Shek","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Keung","family":"Yeung","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry Hin\u2010lee","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine The University of Hong Kong Hong Kong SAR China"},{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/2221081a0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0865fje"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120790"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.06.006"},{"issue":"4","key":"e_1_2_6_6_1","first-page":"351","article-title":"Comparison of age\u2010related changes in wrinkling and sagging of the skin in Caucasian females and in Japanese females","volume":"55","author":"Tsukahara K","year":"2004","journal-title":"J Cosmet Sci"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22540"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22427"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.3045"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22577"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001047"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001333"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000922"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.010"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20976"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.23014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T05:29:30Z","timestamp":1694582970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,28]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/lsm.23014"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23014","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,28]]},"assertion":[{"value":"2018-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}