{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:15:29Z","timestamp":1784816129646,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["201602837"],"award-info":[{"award-number":["201602837"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Dissecting cellulitis of the scalp (DCS) is difficult to be treated and 5\u2010aminolaevulinic acid photodynamic therapy (ALA\u2010PDT) is considered to be a potential treatment for inflammatory skin diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the efficacy and safety of ALA\u2010PDT on DCS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The treatment areas of DCS patients were incubated with freshly prepared 10% ALA for 3 hours. The 633\u2009\u00b1\u200910\u2009nm light with the intensity of 80\u2013100\u2009mw\/cm<jats:sup>2<\/jats:sup> was used as the irradiation source of ALA\u2010PDT, and the irradiation time was 20\u201330 minutes. Three sessions were applied at an interval of 10\u201315 days. According to the reduction of lesions and the improvements of patients\u2019 symptoms after each session, the objective assessment of therapeutic effect was divided into four grades. The adverse effects were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven male DCS patients finished the treatments and assessments. One month after three sessions of treatment, one patient recovered, three patients received significant improvement, and one patients received medium improvement. At the 3\u2010month follow\u2010up, two patients recovered, four patients received significant improvement, and one patients received medium improvement. The patients tolerated well to the therapy without any severe adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>10% ALA\u2010PDT is effective and safe on male DCS patients. As a localized and less invasive treatment, it provides a preferable choice for DCS patients. Lasers Surg. Med. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23016","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T11:19:38Z","timestamp":1535023178000},"page":"332-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Treatment of dissecting cellulitis of the scalp with 10% ALA\u2010PDT"],"prefix":"10.1002","volume":"51","author":[{"given":"Yuxin","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Hospital of China Medical University Shenyang 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