{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:30:34Z","timestamp":1788618634858,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The pulsed\u2010dye laser has long been a gold standard in the treatment of poikiloderma of Civatte. Recent advances in pulsed dye laser technology enable output energies 50% higher, enabling beam diameters of up to 15\u2009mm with clinically relevant fluences. In this study, we investigate this new laser for treatment of this condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty subjects were enrolled in the study. A total of four treatments were administered at monthly intervals. Blinded assessment of digital, cross\u2010polarized photographs taken at baseline and two months following the last treatment was performed by blinded physician raters using an 11\u2010point clearance scale. Subject reported pain scores immediately following treatment and side effects at all visits were recorded by the investigator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen subjects completed the study. Blinded reviewers correctly identified the baseline photo in 48 of 51 cases (94%). All three reviewers mis\u2010identified the same subjects. The blinded reviewers scored 14 out of the 17 subjects with an improvement greater than 40% and 10 out of the 17 subjects greater than 50%. Average improvement was 49% for all 17 subjects. Side effects were limited to mild edema, and mild to moderate erythema and purpura. Pain scores averaged 3.5 on using an 11\u2010point scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates the safety and effectiveness of a new pulsed\u2010dye laser with a 15\u2009mm spot and 50% higher fluences for the treatment of poikiloderma of Civatte. Lasers Surg. Med. 51:54\u201358, 2019. \u00a9 2018 The Authors. <jats:italic>Lasers in Surgery and Medicine<\/jats:italic> Published by Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23036","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T11:49:10Z","timestamp":1543319350000},"page":"54-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Treatment of poikiloderma of Civatte using a redesigned pulsed dye laser with a 15\u2009mm diameter treatment spot"],"prefix":"10.1002","volume":"51","author":[{"given":"Eric F.","family":"Bernstein","sequence":"first","affiliation":[{"name":"Main Line Center for Laser Surgery Ardmore Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Schomacker","sequence":"additional","affiliation":[{"name":"Syneron\u2010Candela Corporation Wayland Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Paranjape","sequence":"additional","affiliation":[{"name":"Syneron\u2010Candela Corporation Wayland Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Jones","sequence":"additional","affiliation":[{"name":"Syneron\u2010Candela Corporation Wayland Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,27]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"605","article-title":"Poikilodermie reticulee pigmentaire du visage et du col","volume":"6","author":"Civatte A","year":"1923","journal-title":"Ann Derm Syph"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.126.4.547b"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000098580"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1990.tb00002.x"},{"key":"e_1_2_6_6_1","first-page":"234","article-title":"Poikiloderma of Civatte. Resolution after treatment with the pulsed dye laser","volume":"55","author":"Clark RE","year":"1994","journal-title":"N C Med J"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14628839950517093"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01782.x"},{"issue":"3","key":"e_1_2_6_9_1","first-page":"314","article-title":"Treatment of poikiloderma of Civatte using intense pulsed light source: 7 years of experience","volume":"34","author":"Rusciani A","year":"2008","journal-title":"Dermatol Surg"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.00060.x"},{"key":"e_1_2_6_11_1","first-page":"1191","article-title":"Treatment of poikiloderma of Civatte with potassium titanyl phosphate (KTP) laser","volume":"140","author":"Batta K","year":"1999","journal-title":"Br J Dermatol"},{"issue":"2","key":"e_1_2_6_12_1","first-page":"298","article-title":"Fractional photothermolysis for treatment of poikiloderma of Civatte","volume":"32","author":"Behroozan DS","year":"2006","journal-title":"Dermatol Surg"},{"issue":"6","key":"e_1_2_6_13_1","first-page":"527","article-title":"Treatment of Poikiloderma of Civatte with ablative fractional laser resurfacing: prospective study and review of the literature","volume":"8","author":"Tierney EP","year":"2009","journal-title":"J Drugs Dermatol"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.23036","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T05:29:45Z","timestamp":1694582985000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,27]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/lsm.23036"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23036","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,27]]},"assertion":[{"value":"2018-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}