{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:30:06Z","timestamp":1764174606622,"version":"3.37.3"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Benign pigmented lesions are among the most common dermatologic diagnoses that patients seek treatments for. Treatment modalities range from cryotherapy to light and laser\u2010based technologies. These treatments have been shown to be effective, yet may lead to dyschromia or significant downtime. Therefore, we report the first clinical experience with a novel Dermal Cooling System that provides localized and controlled freezing to benign pigmented lesions. Twenty patients seeking treatment for benign pigmented lesions were treated with the Dermal Cooling System at the laser and cosmetic dermatology clinic at the University of California, San Diego. Photographs were captured at baseline and follow\u2010up visits. Two blinded investigators reviewed and graded the photographs. Most patients experienced improvement after 1 month following the first treatment. Macular or slightly raised lesions responded best. Treatment side effects were transient, lasted a maximum of 3 days, and included erythema, swelling, itching, and darkening. There was no observed long\u2010term dyschromia. The novel Dermal Cooling System shows promise in the treatment of flat to slightly raised benign pigmented lesions with little\u2010to\u2010no downtime. Further clinical experience is necessary to continue to optimize treatment parameters. Lasers Surg. Med. 51:59\u201361, 2019. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23037","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T11:39:42Z","timestamp":1543318782000},"page":"59-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment of benign pigmented lesions using a novel Dermal Cooling System"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5421-7323","authenticated-orcid":false,"given":"Aria","family":"Vazirnia","sequence":"first","affiliation":[{"name":"Department of Dermatology University of California San Diego La Jolla 92122 California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arisa E.","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California San Diego La Jolla 92122 California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,27]]},"reference":[{"issue":"9","key":"e_1_2_6_2_1","first-page":"835","article-title":"Differential diagnosis of seborrheic keratosis: Clinical and dermoscopic features","volume":"16","author":"Braun RP","year":"2017","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.7.841"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70123-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0011-2240(86)90027-1"},{"issue":"10","key":"e_1_2_6_6_1","first-page":"1119","article-title":"Current understanding of seborrheic keratosis: Prevalence, etiology, clinical presentation, diagnosis, and management","volume":"14","author":"Jackson JM","year":"2015","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_7_1","first-page":"91","article-title":"Cutaneous cryosurgery in the United States","volume":"27","author":"Farhangian ME","year":"2016","journal-title":"J Dermatol Treat"},{"issue":"2","key":"e_1_2_6_8_1","first-page":"9","article-title":"History of cryotherapy","volume":"11","author":"Freiman A","year":"2005","journal-title":"Dermatol Online J"},{"issue":"11","key":"e_1_2_6_9_1","first-page":"1064","article-title":"Managing seborrheic keratoses: Evolving strategies for optimizing patient outcomes","volume":"16","author":"Ranasinghe GC","year":"2017","journal-title":"J Drugs Dermatol"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.23037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T05:29:26Z","timestamp":1694582966000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,27]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/lsm.23037"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23037","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"type":"print","value":"0196-8092"},{"type":"electronic","value":"1096-9101"}],"subject":[],"published":{"date-parts":[[2018,11,27]]},"assertion":[{"value":"2018-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}