{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:40:30Z","timestamp":1789479630757,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"St. Vincent's Hospital, Research Institute of Medical Science","award":["SVHR-2017-02"],"award-info":[{"award-number":["SVHR-2017-02"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The 308\u2010nm excimer laser (EL) has been widely used for localized vitiligo. The recently developed Titanium:Sapphire laser, emits a wavelength of 311\u2009nm, would be expected to be as effective as excimer laser in treatment of vitiligo but few controlled trials have been reported. We sought to compare the efficacy and safety of the TSL and EL as vitiligo treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized controlled non\u2010inferiority trial based on split\u2010body was conducted. Patients with stable vitiligo between June 2016 and May 2017 were enrolled. Paired symmetrical vitiligo lesions were randomized to either the EL or TSL treatment group, and treated with a 308\u2010nm EL or a 311\u2010nm TSL twice weekly for 12 weeks. The extent of repigmentation was assessed every 4 weeks, and the non\u2010inferiority margin was set to 10%. We also recorded any adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010four paired lesions in 21 patients were assigned to both the EL group or TSL group. The mean difference between two groups (EL minus TSL) was \u22122.862%, and the 95% confidence interval (\u22126.531% to 0.807%) was lower than the non\u2010inferiority margin. No serious adverse events were noted in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Titanium:Sapphire laser showed similar therapeutic effect to excimer laser in localized vitiligo with good safety profiles in this non\u2010inferiority randomized controlled trial. The Titanium: Sapphire laser can serve as an alternative treatment option for localized vitiligo. Lasers Surg. Med. 51:239\u2013244, 2019. \u00a9 2019 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23048","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T11:06:36Z","timestamp":1548414396000},"page":"239-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of 311\u2010nm Titanium:Sapphire laser and 308\u2010nm excimer laser treatment for vitiligo: A randomized controlled non\u2010inferiority trial"],"prefix":"10.1002","volume":"51","author":[{"given":"Jung Min","family":"Bae","sequence":"first","affiliation":[{"name":"Department of Dermatology St. Vincent's Hospital College of Medicine The Catholic University of Korea Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hye","family":"Eun","sequence":"additional","affiliation":[{"name":"Department of Dermatology St. Vincent's Hospital College of Medicine The Catholic University of Korea Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Na","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology St. Vincent's Hospital College of Medicine The Catholic University of Korea Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyong Moon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology St. Vincent's Hospital College of Medicine The Catholic University of Korea Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pearl E.","family":"Grimes","sequence":"additional","affiliation":[{"name":"Division of Dermatology Vitiligo &amp; Pigmentation Institute of Southern California David Geffen School of Medicine University of California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology St. Vincent's Hospital College of Medicine The Catholic University of Korea Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15560"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01369.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.11.061"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22821"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11008.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2010.00509.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2005.20.2.273"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12077"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.2175"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2014.26.1.17"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.048"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.12.1613"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000485"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20057"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06321.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01547.x"},{"issue":"5","key":"e_1_2_6_20_1","first-page":"522","article-title":"The excimer lasers","volume":"3","author":"Spencer JM","year":"2004","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-2006-8"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.23048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.23048","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T03:14:47Z","timestamp":1694402087000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,25]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/lsm.23048"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23048","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,25]]},"assertion":[{"value":"2018-11-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}