{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:02:39Z","timestamp":1772002959232,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T00:00:00Z","timestamp":1550534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This PUBA study aimed to assess the efficacy of fractional CO2 laser in the treatment of genitourinary syndrome of menopause (GSM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>GSM symptoms were assessed before, 1 month after the first session and 1 month after the third session of laser (3 sessions with a 30 days interval between them) in 60 women (median, interquartile range: 55, 49\u201369). Subjective (visual analog scale) and objective (Vaginal Health Index, VHIS; Vaginal Maturity Index\/Frost Index; Spanish Overactive Bladder Questionnaire\u2010Short Form, USMEX Spanish OAB\u2010qSF and Female Sexual Function Index, FSFI) measures were used during the study period to assess CO2 fractionated laser treatment outcomes compared to baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fractional CO<jats:sub>2<\/jats:sub> laser treatment was effective to improve GSM symptoms (vaginal dryness, vaginal itching, vaginal burning, dyspaurenia, dysuria, urinary urgency; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) after three sessions, as well as VHIS (median, interquartile range: 13, 10\u201315 at baseline vs. 21, 20\u201323 at the fourth month follow up; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), Frost Index (median, interquartile range: 28, 24\u201331 at baseline vs. 8, 6\u201310 at the fourth month follow up; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), USMEX (median, interquartile range: 56, 46\u201368 at baseline vs 14, 13\u201316 at the fourth month follow up: <jats:italic>P<\/jats:italic>\u2009&lt;\u20090,001) and FSFI (median, interquartile range: 5, 2\u201314 at baseline vs 30, 28\u201332).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this sample, the data suggests that fractionated CO2 laser is an effective alternative for GSM treatment with positive outcomes that persists over time. 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