{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:16:22Z","timestamp":1740104182101,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:00:00Z","timestamp":1557446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2011ZX09302\u2010007\u201003"],"award-info":[{"award-number":["2011ZX09302\u2010007\u201003"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Confocal laser endomicroscopy (CLE) is a novel\u00a0endoscopic technique that can image cells and subcellular layers of the gastric mucosa <jats:italic>in vivo.<\/jats:italic> We aimed to investigate the value of CLE in assessing the quality of ulcer healing (QOUH) and preliminarily establish evaluation criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients with duodenal ulcers were enrolled. After duodenal ulcer healing, we compared the value of CLE and white light endoscopy (WLE) in assessing the QOUH by using the histopathological diagnosis as the gold standard. At the same time, immunohistochemistry was performed to examine the expressions of transforming growth factor \u03b21 (TGF\u2010\u03b21) and fibroblast growth factor 2 (FGF\u20102) in normal and scar tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In assessing the QOUH classified as poor, good, and excellent by the pathological classification, the sensitivity of WLE was 57.14%, 50%, and 47.06%, the specificity was 87.80%, 52.38%, and 81.58%, and the accuracy was 80.00%, 50.91%, and 70.91%, respectively. Meanwhile, the sensitivity of CLE was 73.33%, 85.19%, and 92.31%, the specificity was 95%, 85.71%, and 92.86%, and the accuracy was 89.09%, 85.45%, and 92.73%, respectively. The <jats:italic>\u03ba<\/jats:italic> value for the correlation with pathological diagnosis grade was 0.38 for WLE vs. 0.74 for CLE. The assessment of the QOUH in the CLE image classification showed great improvement compared with that in the WLE image classification. The image classification of CLE was not associated with the immunohistochemical expression of TGF\u2010\u03b21 or FGF\u20102 according the Spearman rank correlation (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with WLE, CLE has a higher value in assessing the QOUH. Lasers Surg. Med. \u00a9 2019 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23098","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T11:20:32Z","timestamp":1557487232000},"page":"701-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Value of Confocal Laser Endoscopy in Assessing the Quality of Duodenal Ulcer Healing"],"prefix":"10.1002","volume":"51","author":[{"given":"Jianfang","family":"Rong","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanchang University  Nanchang 330006 Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical The First Affiliated Hospital of Jiangxi Medical College  Shangrao 334000 Jiangxi 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