{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T12:51:42Z","timestamp":1774183902480,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>To evaluate safety and efficacy of treatment with the picosecond Nd:YAG 532\u2009nm for\u00a0lentigines in Asian skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>This was a prospective, open\u2010label cohort study, using a novel picosecond 532\u2010nm laser for the treatment\u00a0of facial lentigines. Subjects received up to three laser treatments every 4\u20136 weeks and were assessed at 4 and 12 weeks after final treatment. Primary endpoint was degree of improvement in lentigines at 12 weeks after the final treatment, assessed by treating investigator based on Physicians Global Assessment. Secondary end\u2010points included degree of improvement in lentigines at 12 weeks after final treatment, assessed by subject (Subject's Global Assessment), and change in mean relative Melanin index (MI) value at 3 months after final treatment as compared to baseline as assessed by mexameter measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 20 patients (3 male, and 17 female) of Asian\u2010descent with Fitzpatrick skin type III and IV, with lentigines on the face were included in this study. A total of 89 lesions were treated with the laser setting of 532\u2010nm, 750 picoseconds, fluence of 0.2\u20130.5\u2009J\/cm\n<jats:sup>2<\/jats:sup>, and spot size of 4\u2009mm. One hundred and thirty\u2010seven treatment sessions were given in total. Eighteen patients (90%) achieved a moderate to significant improvement at 12\u2010week follow\u2010up based on a 5\u2010grade physician global assessment scale. The improvement rate of relative MI (MI in the lesion minus normal skin) was 33.30\u2009\u00b1\u200918.71 and 37.63\u2009\u00b1\u200919.25% at 4\u2010 and 12\u2010week follow\u2010up. Post\u2010inflammatory hyperpigmentation (PIH) occurred in 14 of 137 sessions (10.2%), and hypopigmentation occurred in one patient with five lesions (3.6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that using picosecond Nd:YAG laser 532\u2009nm for removal of solar lentigines in darker skin type appears to be safe and effective. Lasers Surg. Med. \u00a9 2019 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>Small study group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23103","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T06:01:52Z","timestamp":1558504912000},"page":"767-773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["A Prospective Study in the Treatment of Lentigines in Asian Skin Using 532\u2009nm Picosecond Nd:YAG Laser"],"prefix":"10.1002","volume":"51","author":[{"given":"Mandy W.M.","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Dermatology The University of Hong Kong 4\/F, Professorial Block, Queen Mary Hospital, 102 Pok Fu Lam Road Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha Yee\u2010Nam","family":"Shek","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Dermatology The University of Hong Kong 4\/F, Professorial Block, Queen Mary Hospital, 102 Pok Fu Lam Road Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Keung","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Dermatology The University of Hong Kong 4\/F, Professorial Block, Queen Mary Hospital, 102 Pok Fu Lam Road Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9657-1435","authenticated-orcid":false,"given":"Henry Hin\u2010Lee","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Dermatology The University of Hong Kong 4\/F, Professorial Block, Queen Mary Hospital, 102 Pok Fu Lam Road Hong Kong SAR China"},{"name":"Wellman Center for Photomedicine Dermatology Service at Massachusetts General Hospital 55 Fruit Street Boston Boston MA 02114 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,21]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.12.043"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2560-3"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22820"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.01.012"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.2.167"},{"key":"e_1_2_6_1_7_1","first-page":"1002","article-title":"Efficacy and safety of intense pulsed light with a KTP filter for the treatment of solar lentigines","volume":"10","author":"Friedmann DP","year":"2019","journal-title":"Lasers Surg Med"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12277339"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"crossref","first-page":"pp. 81","DOI":"10.1159\/000328267","volume-title":"Basics in Dermatological Laser Applications. 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