{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:55:41Z","timestamp":1784159741333,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T00:00:00Z","timestamp":1563062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012430","name":"Center for Emerging and Innovative Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012430","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Hospital\u2010acquired infections (HAIs) and multidrug resistant bacteria pose a significant threat to the U.S. healthcare system. With a dearth of new antibiotic approvals, novel antimicrobial strategies are required to help solve this problem. Violet\u2010blue visible light (400\u2013470\u2009nm) has been shown to elicit strong antimicrobial effects toward many pathogens, including representatives of the ESKAPE bacterial pathogens, which have a high propensity to cause HAIs. However, phototherapeutic solutions to prevention or treating infections are currently limited by efficient and nonobtrusive light\u2010delivery mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Here, we investigate the in vitro antimicrobial properties of flexible Corning\u00ae light\u2010diffusing fiber (LDF) toward members of the ESKAPE pathogens in a variety of growth states and in the context of biological materials. Bacteria were grown on agar surfaces, in liquid culture and on abiotic surfaces. We also explored the effects of 405\u2009nm light within the presence of lung surfactant, human serum, and on eukaryotic cells. Pathogens tested include<jats:italic>Enterococcus spp, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp., Staphylococcus epidermidis, Streptococcus pyogenes, Candida albicans<\/jats:italic>, and<jats:italic>Escherichia coli<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, the LDF delivery of 405\u2009nm violet\u2010blue light exerted a significant degree of microbicidal activity against a wide range of pathogens under diverse experimental conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results exemplify the fiber's promise as a non\u2010traditional approach for the prevention and\/or therapeutic intervention of HAIs. Lasers Surg. Med. \u00a9 2019 The Authors.<jats:italic>Lasers in Surgery and Medicine<\/jats:italic>Published by Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23132","type":"journal-article","created":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T10:08:15Z","timestamp":1563098895000},"page":"887-896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Characterizing the Antimicrobial Properties of 405\u2009nm Light and the Corning\u00ae Light\u2010Diffusing Fiber Delivery System"],"prefix":"10.1002","volume":"51","author":[{"given":"Cindy","family":"Shehatou","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology University of Rochester School of Medicine and Dentistry Rochester New York 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan L.","family":"Logunov","sequence":"additional","affiliation":[{"name":"Division of Science and Technology Corning Research &amp; Development Corporation Corning New York 14831"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Dunman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Rochester School of Medicine and Dentistry Rochester New York 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine G.","family":"Haidaris","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Rochester School of Medicine and Dentistry Rochester New York 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0157-0414","authenticated-orcid":false,"given":"W. 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