{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T15:48:16Z","timestamp":1769096896296,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Varieties of laser and light sources have been tried for treatment of alopecia areata (AA) and some success has been reported. To assess the effectiveness of 1,540\u2009\u2009nm fractional erbium\u2010glass laser in treatment of AA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>The patches of AA were divided into two groups, the study group (I) underwent six sessions of laser therapy at weekly interval with topical minoxidil solution applied twice daily for 6 weeks, while group (II), the control group was received only topical minoxidil solution. The patches were evaluated objectively (hair count and percentage of regrowth) and subjectively (patient satisfaction) at the end of follow\u2010up period (another 6 weeks).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The percentage of hair increment between pre\u2010treatment and follow\u2010up period was 30% for study patches versus 6.45% for control patches. Regarding the percentage of growth, the response rate for study patches was 60% versus 16% for the control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Erbium\u2010glass laser seems to be effective in regrowing hair in AA. The durability of the response is unknown. Possible mechanisms of improvement include the induction of a thermal effect on papillary dermis, which stimulates hair regrowth, or an immunological effect on the follicle. In addition, the erbium\u2010glass laser may enhance the delivery of minoxidil solution. Lasers Surg. Med. \u00a9 2019 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23133","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T04:49:45Z","timestamp":1563511785000},"page":"859-865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Use of a 1,540\u2009nm Fractional Erbium\u2010Glass Laser in Treatment of Alopecia Areata"],"prefix":"10.1002","volume":"51","author":[{"given":"Muhsin A.","family":"Al\u2010Dhalimi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine University of Kufa  Najaf 54001 Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1286-4688","authenticated-orcid":false,"given":"Murtadha H.","family":"Al\u2010Janabi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine University of Kufa  Najaf 54001 Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruqeya A.","family":"Abd Al Hussein","sequence":"additional","affiliation":[{"name":"Department of Dermatology Al\u2010Sader Medical City  Najaf 54001 Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,18]]},"reference":[{"key":"e_1_2_6_1_2_1","first-page":"2289","volume-title":"Rook's Textbook of Dermatology","author":"Messenger AG","year":"2016"},{"key":"e_1_2_6_1_3_1","first-page":"848","author":"William D","year":"2012","journal-title":"Andrews\u2019 Diseases of the Skin Clinical Dermatology"},{"key":"e_1_2_6_1_4_1","first-page":"367","article-title":"Alopecia areata: genetic complexity underlies clinical heterogeneity","volume":"17","author":"Subramanya RD","year":"2007","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01833.x"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2306-7"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.4172\/2471-9323.1000108"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22227"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.113954"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2009.00980.x"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170600607368"},{"issue":"2","key":"e_1_2_6_1_12_1","first-page":"460","article-title":"Efficacy of low level laser therapy in the treatment of alopecia areata","volume":"2","author":"Abdelhalim NM","year":"2014","journal-title":"Int J Physiother Res"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01833.x"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2013.764436"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12003"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20048"},{"issue":"3","key":"e_1_2_6_1_17_1","first-page":"187","article-title":"Topical minoxidil in androgenetic alopecia, how good is it","volume":"56","author":"Kubba R","year":"1990","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05785.x"},{"key":"e_1_2_6_1_19_1","unstructured":"BadenHP.Selective action of minoxidil on arachidonic acid metabolism of cells in culture. Presented at the Brook Lodge Symposium androgenetic alopecia. Kalamazoo Michigan: The Upjohn Company;1987."},{"key":"e_1_2_6_1_20_1","first-page":"295","volume-title":"Minoxidil and Neoptide Topical Application Reinforced by Low\u2010Level Laser Therapy on an Animal Model of Alopecia","author":"Or\u0103sana MS","year":"2015"},{"key":"e_1_2_6_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22227"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.23133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.23133","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T05:38:15Z","timestamp":1694237895000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,18]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/lsm.23133"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23133","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,18]]},"assertion":[{"value":"2019-06-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}