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Straight\u2010 and diffusion\u2010type LLLI were applied directly into the intranasal cavity of the mice once daily for 10 days (650\u2009nm, 5\u2009mW, 15\u2009min\/day) and multiple allergic parameters were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LLLI reduced allergic symptoms, such as rubbing and sneezing, and suppressed the serum total immunoglobulin E (IgE), OVA\u2010specific IgE, and OVA\u2010specific IgG1 levels. Diffusion\u2010type LLLI significantly reduced eosinophil infiltration of nasal mucosa and lymph nodes (LNs). LLLI reduced the expression of interleukin\u20104 (IL\u20104) and IL\u201017 in cervical LN and splenocyte culture supernatant, as well as their messenger RNA levels in nasal mucosa. However, the expression of interferon\u03b3 (IFN\u2010\u03b3) and IL\u20106 was unaffected by LLLI. The levels of reactive oxygen species (ROS) and nitric oxide (NO) in LN cells and the nasal mucosa, which were increased in the AR group, were reduced by LLLI, suggesting involvement of ROS and NO within their mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LLLI exerted an antiallergic effect by decreasing local and systemic IL\u20104, IL\u201017, and IgE levels, as well as eosinophilic infiltration into the nasal mucosa, in a mouse model of AR by modulating ROS and NO levels. Diffusion\u2010type LLLI exhibited greater efficacy against AR than straight\u2010type LLLI. Lasers Surg. Med. \u00a9 2019 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23141","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T04:19:45Z","timestamp":1563941985000},"page":"347-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Low\u2010Level Laser Irradiation in a Mouse Model of Allergic Rhinitis"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2589-797X","authenticated-orcid":false,"given":"Jun\u2010Sang","family":"Bae","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Dankook University College of Medicine  Cheonan 31116 Republic of Korea"},{"name":"Beckman Laser Institute Korea Dankook University College of Medicine  Cheonan 31116 Republic of 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