{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:27:15Z","timestamp":1783441635448,"version":"3.54.6"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T00:00:00Z","timestamp":1568505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>There is a clinical need to assess the resection margins of tongue cancer specimens, intraoperatively. In the current<jats:italic>ex vivo<\/jats:italic>study, we evaluated the feasibility of hyperspectral diffuse reflectance imaging (HSI) for distinguishing tumor from the healthy tongue tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Fresh surgical specimens (<jats:italic>n<\/jats:italic>\u2009=\u200914) of squamous cell carcinoma of the tongue were scanned with two hyperspectral cameras that cover the visible and near\u2010infrared spectrum (400\u20131,700\u2009nm). Each pixel of the hyperspectral image represents a measure of the diffuse optical reflectance. A neural network was used for tissue\u2010type prediction of the hyperspectral images of the visual and near\u2010infrared data sets separately as well as both data sets combined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HSI was able to distinguish tumor from muscle with a good accuracy. The diagnostic performance of both wavelength ranges (sensitivity\/specificity of visual and near\u2010infrared were 84%\/80% and 77%\/77%, respectively) appears to be comparable and there is no additional benefit of combining the two wavelength ranges (sensitivity and specificity were 83%\/76%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HSI has a strong potential for intra\u2010operative assessment of tumor resection margins of squamous cell carcinoma of the tongue. This may optimize surgery, as the entire resection surface can be scanned in a single run and the results can be readily available. Lasers Surg. Med. \u00a9 2019 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23161","type":"journal-article","created":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T15:53:56Z","timestamp":1568562836000},"page":"496-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Toward assessment of resection margins using hyperspectral diffuse reflection imaging (400\u20131,700\u2009nm) during tongue cancer surgery"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0171-6759","authenticated-orcid":false,"given":"Susan G.","family":"Brouwer de Koning","sequence":"first","affiliation":[{"name":"Department of Surgery, Netherlands Cancer Institute Antoni van Leeuwenhoek Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"Weijtmans","sequence":"additional","affiliation":[{"name":"Department of In\u2010Body Systems Philips Research Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Baris","family":"Karakullukcu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Netherlands Cancer Institute Antoni van Leeuwenhoek Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caifeng","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of In\u2010Body Systems Philips Research Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth J. M.","family":"Baltussen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Netherlands Cancer Institute Antoni van Leeuwenhoek Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Smit","sequence":"additional","affiliation":[{"name":"Department of Pathology, Netherlands Cancer Institute Antoni van Leeuwenhoek Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L. 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