{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:10:35Z","timestamp":1783653035549,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,10]],"date-time":"2019-11-10T00:00:00Z","timestamp":1573344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Pulsed\u2010dye laser (PDL) and oxymetazoline 1.0% cream are each used for the treatment of erythematotelangiectatic (ET) rosacea. PDL targets oxyhemoglobin and can reduce facial erythema and telangiectasias. Oxymetazoline 1.0% cream is an \u03b1 adrenergic agonist, which has shown to reduce facial erythema. The aim of this study was to determine the degree of erythema improvement and telangiectasia clearance after combination treatment with PDL plus oxymetazoline 1.0% cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>This retrospective study was conducted at two sites. Pre\u2010 and post\u2010treatment cross\u2010polarized images from subjects on combination treatment with PDL and oxymetazoline 1.0% cream were graded by a board\u2010certified dermatologist at each practice. Blinded images were analyzed using the Clinical Erythema Assessment (CEA) Scale (0\u2009=\u2009clear and 4\u2009=\u2009severe). Unblinded images were analyzed using the five\u2010point Telangiectasia Scale to determine the degree of improvement post\u2010treatment compared with baseline (1\u2009=\u2009&lt;5% clearance and 5\u2009=\u200975\u2013100% clearance).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one subjects (20 females, 11 males) of age 51\u2009\u00b1\u200913 years (mean\u2009\u00b1\u2009standard deviation) were included in the study after an average of 4 months (range: 1\u201313) of daily oxymetazoline 1.0% cream and two (range: 1\u20134) PDL treatments. At baseline, 87% of subjects had CEA Grade 2 (mild erythema) or higher. For erythema, 55% of subjects improved by at least one CEA grade and 13% achieved two grades of improvement post\u2010treatment. For telangiectasias, 90% of subjects achieved at least a two\u2010point clearance (5\u201325%), 62% at least a three\u2010point clearance (25\u201350%), and 41% at least a four\u2010point clearance (50\u201375%) post\u2010treatment. Compared with subjects with baseline CEA Grade 1\u20132 (almost clear to mild erythema), significantly more subjects with baseline CEA Grade 3\u20134 (moderate to severe erythema) achieved at least one CEA grade of improvement (<jats:italic>P<\/jats:italic>\u2009=\u20090.021) and two grades of CEA improvement (<jats:italic>P<\/jats:italic>\u2009=\u20090.041). A higher percentage of baseline CEA Grade 3\u20134 subjects achieved at least a two\u2010point clearance in telangiectasias (<jats:italic>P<\/jats:italic>\u2009=\u20090.055).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combination treatment with PDL and daily oxymetazoline 1.0% cream can safely and effectively reduce erythema and telangiectasias. Limitations include the retrospective design of the study, small sample size, and lack of a control group. Lasers Surg. Med. \u00a9 2019 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23176","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T04:05:02Z","timestamp":1573445102000},"page":"38-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Treatment of Erythematotelangiectatic Rosacea With Pulsed\u2010Dye Laser and Oxymetazoline 1.0% Cream: A Retrospective Study"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6203-9857","authenticated-orcid":false,"given":"Amanda K.","family":"Suggs","sequence":"first","affiliation":[{"name":"Dermatology &amp; Laser Surgery Center  6400 Fannin St Suite 2720 Houston Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Macri","sequence":"additional","affiliation":[{"name":"Dermatology, Laser &amp; Vein Specialists of the Carolinas  1918 Randolph Rd #550 Charlotte North Carolina 28207"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Richmond","sequence":"additional","affiliation":[{"name":"Dermatology &amp; Laser Surgery Center  6400 Fannin St Suite 2720 Houston Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilly","family":"Munavalli","sequence":"additional","affiliation":[{"name":"Dermatology, Laser &amp; Vein Specialists of the Carolinas  1918 Randolph Rd #550 Charlotte North Carolina 28207"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Dermatology &amp; Laser Surgery Center  6400 Fannin St Suite 2720 Houston Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20621"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22819"},{"key":"e_1_2_6_5_1","first-page":"1","article-title":"Evaluation of long\u2010term efficacy, safety, and effect on life quality of pulsed dye laser in rosacea patients","volume":"24","author":"Bulbul Baskan E","year":"2018","journal-title":"J Cosmet Laser Ther"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.01.027"},{"issue":"3","key":"e_1_2_6_7_1","first-page":"308","article-title":"Phase 2 randomized, dose\u2010ranging study of oxymetazoline cream for treatment of persistent facial erythema associated with rosacea","volume":"17","author":"DuBois 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