{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:01:30Z","timestamp":1788368490744,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,10]],"date-time":"2019-11-10T00:00:00Z","timestamp":1573344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Recently, picosecond laser treatment has been used as an effective treatment for acne scars. To evaluate the efficacy and safety of a picosecond alexandrite laser with a diffractive lens array in the treatment of acne scars in Chinese patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Patients with facial acne scars were treated with a picosecond alexandrite laser in three sessions at 4\u2010 to 6\u2010week intervals and followed up for 2 months. Primary outcomes were measured by physicians\u2019 blinded evaluation of the acne scar using the ECCA (\u00e9chelle d\u2019\u00e9va physicians'luation clinique des cicatrices d'acn\u00e9) grading scale. The secondary outcomes included the investigator global assessment (IGA) on the improvement of post\u2010inflammatory erythema (PIE), patients\u2019 assessment of improvement on a 4\u2010point scale and of satisfaction on a 5\u2010point scale. Pain scores and adverse effects were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Twenty patients with Fitzpatrick skin types III and IV were enrolled in the study and completed all treatment and follow\u2010up visits. The mean ECCA scores fell from 197.75\u2009\u00b1\u200935.26 to 142.00\u2009\u00b1\u200935.92 (a 28% improvement), and the change was significant (<jats:italic>P<\/jats:italic>\u2009=\u20090.000). The mean IGA score of PIE improvement was 3.03\u2009\u00b1\u20090.75 (0\u2009=\u2009no improvement and 4\u2009=\u200976\u2013100% improvement). On the basis of the patients\u2019 self\u2010assessment, the average improvement scores were 2.30\u2009\u00b1\u20090.98 (0 indicating 0\u201325% improvement and 3 indicating &gt;75% improvement). In total, 50% and 30% of the patients were \u201csatisfied\u201d and \u201cvery satisfied,\u201d respectively, with the treatment. The mean pain score was 3.20\u2009\u00b1\u20090.50 (0\u2009=\u2009no pain, 10\u2009=\u2009maximum pain) with topical anesthesia. The adverse effects included transient and mild erythema, edema, and scabbing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with a picosecond alexandrite laser with a diffractive lens array is effective and safe for acne scars in Chinese patients. Lasers Surg. Med. \u00a9 2019 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23177","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T04:06:40Z","timestamp":1573445200000},"page":"176-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Evaluation of the Safety and Efficacy of a Picosecond Alexandrite Laser With DLA for Acne Scars in Chinese Patients"],"prefix":"10.1002","volume":"52","author":[{"given":"Mengli","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cosmetic Laser Surgery, Hospital of Dermatology, Chinese Academy of Medical Sciences Peking Union Medical College  Nanjing 210042 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Laser Surgery, Hospital of Dermatology, Chinese Academy of Medical Sciences Peking Union Medical College  Nanjing 210042 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7720-4982","authenticated-orcid":false,"given":"Qiuju","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Laser Surgery, Hospital of Dermatology, Chinese Academy of Medical Sciences Peking Union Medical College  Nanjing 210042 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Laser Surgery, Hospital of Dermatology, Chinese Academy of Medical Sciences Peking Union Medical College  Nanjing 210042 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2006.00079.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2006.00143.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.3045"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001669"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22763"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12103"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000096912"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2164"},{"issue":"11","key":"e_1_2_6_11_1","first-page":"1077","article-title":"Treatment of photoaging with a dual\u2010wavelength, 532 nm and 1,064 nm picosecond\u2010domain laser producing a fractionated treatment beam using a holographic optic","volume":"16","author":"Bernstein EF","year":"2017","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02662.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2013.854639"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.07.047"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22443"},{"issue":"11","key":"e_1_2_6_16_1","first-page":"1390","article-title":"A prospective split\u2010face study of the picosecond alexandrite laser with specialized lens array for facial photoaging in Chinese","volume":"15","author":"Ge Y","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23014"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22540"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22734"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_306_17"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20209"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.23177","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T16:44:17Z","timestamp":1694105057000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,10]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/lsm.23177"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23177","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,10]]},"assertion":[{"value":"2019-10-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}