{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:40:42Z","timestamp":1779892842177,"version":"3.53.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61575221"],"award-info":[{"award-number":["61575221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Widespread applications of supercontinuum (SC) source lead to the possibility of ocular damages. However, the corneal damage effects induced by SC have not been explored before. The objectives of this study are to determine the rabbit corneal injury threshold for SC radiation and to examine whether the existing safety guidelines and standards are suitable for the hazard evaluation of this new kind of light source.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>A series of experiments was conducted in the New Zealand white rabbit model to determine the corneal damage thresholds induced by a 770\u20132,500\u2009nm SC source, with a corneal 1\/e beam diameter of 0.37\u2009mm. Through slit\u2010lamp biomicroscope, optical coherence tomography (OCT), and histopathology the corneal damage characteristics at the threshold level were revealed. By employing the action spectra determined through the analysis of safety guidelines and standards, the damage thresholds for SC source could be compared with the corresponding exposure limits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The determined damage thresholds given in terms of the peak radiant exposure for exposure durations of 2.0 and 10.0\u2009seconds were 2.1\u2009\u00d7\u200910<jats:sup>3<\/jats:sup> and 7.4\u2009\u00d7\u200910<jats:sup>3<\/jats:sup>\u2009J\/cm<jats:sup>2<\/jats:sup>, respectively. At threshold level, corneal damages involved the epithelium and the shallower stroma, and no obvious changes could be found in the deep stroma, Descemet's membrane, and endothelium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The exposure limits for the anterior parts of the eye in the wavelength range of 700\u20131,200\u2009nm are overly conservative. The obtained results contribute to the knowledge base for the hazard evaluation of SC source. Lasers Surg. Med. \u00a9 2019 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23182","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T04:19:26Z","timestamp":1573532366000},"page":"560-568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Corneal Damage Effects Induced by a 770\u20132,500\u2009nm Supercontinuum Light Source"],"prefix":"10.1002","volume":"52","author":[{"given":"Luguang","family":"Jiao","sequence":"first","affiliation":[{"name":"Beijing Institute of Radiation Medicine Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Fan","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing 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