{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:04:05Z","timestamp":1783127045010,"version":"3.54.6"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2020,7]]},"abstract":"Background and Objective<\/jats:title>Keratosis pilaris (KP) is\u00a0a common\u00a0follicular disorder for which various topical agents and energy\u2010based devices have been used with some efficacy. To evaluate the efficacy of a novel 1064\u2010nm Nd:YAG laser for the reduction of skin roughness, erythema, and hyperpigmentation in KP subjects.<\/jats:p><\/jats:sec>Study Design\/Materials and Methods<\/jats:title>Twenty\u2010three subjects with untreated KP on the upper outer arms participated in a randomized, single\u2010blind fashion. One arm of each subject was divided into upper and lower parts. One part was randomized to be treated with an innovative 1064\u2010nm Nd:YAG laser, while the other part received sham irradiation. Subjects received four consecutive treatments at 4\u2010week intervals. Antera3D was used to measure skin roughness, erythema, and hyperpigmentation at baseline and 4 weeks after the last treatment. Moreover, clinical outcomes were also evaluated by subjects' Global Improvement Score (GIS) and subjects' satisfaction grading scores.<\/jats:p><\/jats:sec>Results<\/jats:title>Twenty\u2010three subjects completed the study. There was statistically significant reduction of skin roughness measured by Antera3D compared with control group (P\u2009<\/jats:italic><\u20090.001). There were statistically significant improvements of skin roughness, erythema, hyperpigmentation, and overall appearances graded by subjects' Global Improvement Score (P\u2009<\/jats:italic><\u20090.001 all). Subjects' satisfaction scores were graded significantly better in treatment parts (P\u2009<\/jats:italic><\u20090.001). No adverse events including burning, bulla, erosion, post\u2010inflammatory hyper\/hypopigmentation, and scar formation developed in any subjects throughout the study period.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This innovative 1064\u2010nm Nd:YAG laser has proved to significantly and safely reduce skin roughness in Thai KP subjects compared with control after four sessions. Lasers Surg. Med. \u00a9 2019 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23184","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T04:19:14Z","timestamp":1573532354000},"page":"509-514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Innovative 1064\u2010nm Nd:YAG Laser Significantly Improves Keratosis Pilaris, A Randomized, Double\u2010Blind, Sham\u2010Irradiation\u2010Controlled Trial"],"prefix":"10.1002","volume":"52","author":[{"given":"Praewvanid","family":"Maitriwong","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Dermatology, Faculty of Medicine Chulalongkorn University 1873 Rama 4 Road Bangkok 10330 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsinee","family":"Tangkijngamvong","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Dermatology, Faculty of Medicine 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