{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:43:19Z","timestamp":1782398599468,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>CO<jats:sub>2<\/jats:sub> laser cordectomy has been the workhorse of laser surgery for early glottic squamous cell carcinoma (GSCC) since the early 1970s. During the last decades, potassium titanyl phosphate (KTP) laser surgery for early GSCC gained popularity, introducing the tumor ablation technique. Yet, there are no previous randomized controlled trials (RCT) that compare the oncologic and functional outcomes of KTP Laser ablation versus CO<jats:sub>2<\/jats:sub> laser cordectomy for early GSCC. This study aims to compare by means of an RCT, CO<jats:sub>2<\/jats:sub> laser cordectomy with KTP laser ablation for early GSCC, in terms of cure rates and vocal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>A RCT conducted between 2013 and 2017. Patients with early GSCC were enrolled, and randomly assigned for either CO<jats:sub>2<\/jats:sub> cordectomy or KTP\u2010ablation surgery with curative intent. All CO<jats:sub>2<\/jats:sub> cordectomies and most KTP\u2010ablation procedures were performed under general anesthesia. Some KTP cases with residual disease were treated also under local anesthesia. Videostroboscopy measures, voice handicap index (VHI), GRBAS (a hoarseness scale for Grade, Roughness, Breathiness, Asthenia and Strain) score, and\u00a0acoustic analyses were performed pre\u2010operatively, 6 months and 3 years after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four patients, 12 in each group, were enrolled. Nine in each group had T1a carcinoma, the remaining had either carcinoma <jats:italic>in situ<\/jats:italic> or T1b. The average number of procedures was 1.67(\u2009\u00b1\u20090.89) and 1.33(\u2009\u00b1\u20090.89) for the KTP and CO<jats:sub>2<\/jats:sub> groups, respectively. Although the tumor depth was comparable in both groups, patients in the KTP\u2010ablation group underwent more superficial surgeries. Eleven (91.7%) procedures in the KTP group spared the vocal ligament, compared with 5 (41.7%) in the CO<jats:sub>2<\/jats:sub> group, (<jats:italic>P<\/jats:italic>\u2009=\u20090.023). All patients were alive and disease\u2010free after four years. On post\u2010operative videostroboscopy, normal mucosal waves appeared in 5 (42%) of the KTP patients versus none (0%) of the CO<jats:sub>2<\/jats:sub> (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). The median post\u2010operative non\u2010vibrating portion was smaller in the KTP group (10%) compared with CO<jats:sub>2<\/jats:sub> (50%), <jats:italic>P<\/jats:italic>\u2009=\u20090.043. Nevertheless, GRBAS and VHI scores improved comparably in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>KTP ablation technique offers similar curative outcome as CO<jats:sub>2<\/jats:sub> cordectomy but may allow for better preservation of vocal fold's architecture and function. Yet, the clinical significance of these findings is unclear, since the subjective measures improved comparably for these two treatment modalities. Lasers Surg. Med. \u00a9 2019 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23202","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T04:20:52Z","timestamp":1576124452000},"page":"612-620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["CO<sub>2<\/sub> Laser Cordectomy Versus KTP Laser Tumor Ablation for Early Glottic Cancer: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5535-9235","authenticated-orcid":false,"given":"Yonatan","family":"Lahav","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Kaplan Medical Center  POB 1, Pasternak Rd Rehovot Israel"},{"name":"Faculty of Medicine The Hebrew University  Ein Kerem, POB 12000 Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8666-3571","authenticated-orcid":false,"given":"Oded","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Kaplan Medical Center  POB 1, Pasternak Rd Rehovot Israel"},{"name":"Faculty of Medicine The Hebrew University  Ein Kerem, POB 12000 Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Shapira\u2010Galitz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Kaplan Medical Center  POB 1, Pasternak Rd Rehovot Israel"},{"name":"Faculty of Medicine The Hebrew University  Ein Kerem, POB 12000 Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Halperin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Kaplan Medical Center  POB 1, Pasternak Rd Rehovot Israel"},{"name":"Faculty of Medicine The Hebrew University  Ein Kerem, POB 12000 Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4704-2940","authenticated-orcid":false,"given":"Hagit","family":"Shoffel\u2010Havakuk","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Rabin Medical Center  39 Ze'ev Jabotinski St Petach\u2010Tikva 4941492 Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv 6997801 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948909800901"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.10"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20135"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410300104"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000184524.23282.74"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200202000-00030"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815577103"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21226"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947208100606"},{"issue":"5","key":"e_1_2_7_11_1","first-page":"595","article-title":"The use of CO2 laser in otolaryngology: a progress report","volume":"82","author":"Strong MS","year":"1976","journal-title":"Trans Sect Otolaryngol Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(93)90050-H"},{"key":"e_1_2_7_13_1","first-page":"888","volume-title":"Cummings Otolaryngology\u2014Head & Neck Surgery","author":"Garrett CG","year":"2015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00231"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25789"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/00034894081170S701","article-title":"Photoangiolytic laser treatment of early glottic cancer: a new management strategy","volume":"199","author":"Sm1 Zeitels","year":"2008","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-012-1121-4"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26853"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25474"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2016.12.003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2013.01.015"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2005.08.006"},{"key":"e_1_2_7_23_1","unstructured":"National Comprehensive Cancer Network. 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