{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:25:07Z","timestamp":1775535907948,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Economic Development and Innovation Operational Program Grant of the European Union and Hungary","award":["GINOP-2.1.1-15-2016-00783"],"award-info":[{"award-number":["GINOP-2.1.1-15-2016-00783"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Most recently vaginal laser treatment was introduced as a new option for women with genitourinary syndrome of menopause, vaginal dryness. Our objective was to assess the effects of intravaginal CO<jats:sub>2<\/jats:sub> laser treatment on vaginal cytology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Fifty\u2010two women with symptoms of vaginal dryness were enrolled and underwent vaginal laser treatment using a fractional CO<jats:sub>2<\/jats:sub> laser. Patients received three vaginal laser treatments 4 weeks apart. Vaginal cytology was obtained before the first treatment and 4 weeks after each additional treatment. Vaginal dryness was assessed by using a Visual Analog Scale (VAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of the 52 women enrolled, 34 were in menopause. Postmenopausal women had significantly lower vaginal maturation values (VMV) compared with premenopausal women at the baseline visit (mean\u2009\u00b1\u2009standard deviation [SD], 42\u2009\u00b1\u200923 vs. 68\u2009\u00b1\u200913, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The vaginal dryness VAS was higher (worse) in postmenopausal women compared with premenopausal cases (mean\u2009\u00b1\u2009SD, 5.7\u2009\u00b1\u20094 vs. 2.4\u2009\u00b1\u20093, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The VMV did not change significantly over time after vaginal laser treatment. However vaginal dryness VAS improved significantly after each treatment. Both in the premenopausal and postmenopausal groups, vaginal dryness scores improved significantly from baseline after the three treatments (postmenopausal 5.7\u2009\u00b1\u20094 vs. 1.6\u2009\u00b1\u20092.5, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01 and premenopausal 2.4\u2009\u00b1\u20093 vs. 0.2\u2009\u00b1\u20090.5, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Those patients who had improvement in VMV had significantly better (lower) dryness VAS compared with those women without an improvement in VMV after the three treatments (mean\u2009\u00b1\u2009SD, 0.3\u2009\u00b1\u20090.8 vs. 1.6\u2009\u00b1\u20092.6, <jats:italic>P<\/jats:italic>\u2009=\u20090.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vaginal dryness VAS improved significantly in a cohort of premenopausal and postmenopausal women undergoing vaginal CO<jats:sub>2<\/jats:sub> laser treatment despite no significant change in vaginal cytology. Lasers Surg. Med. \u00a9 2020 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23211","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T04:06:55Z","timestamp":1578629215000},"page":"708-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The Effect of Vaginal Microablative Fractional CO<sub>2<\/sub> Laser Treatment on Vaginal Cytology"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0078-5763","authenticated-orcid":false,"given":"Peter","family":"Takacs","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery Eastern Virginia Medical School 825 Fairfax Avenue, Suite 526 Norfolk Virginia 23507\u20102007"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4640-0184","authenticated-orcid":false,"given":"Attila Gergely","family":"Sipos","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Debrecen Faculty of Medicine Pf. 400 H\u20104002 Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bence","family":"Kozma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Debrecen Faculty of Medicine Pf. 400 H\u20104002 Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina D.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"The Center for Health Analytics and Discovery 825 Fairfax Avenue Suite 526 Norfolk Virginia 23507\u20102007"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kindra","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery Eastern Virginia Medical School 825 Fairfax Avenue, Suite 526 Norfolk Virginia 23507\u20102007"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Lamp\u00e9","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Debrecen Faculty of Medicine Pf. 400 H\u20104002 Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Poka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Debrecen Faculty of Medicine Pf. 400 H\u20104002 Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000329"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0b013e3182a122c2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.07.045"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S44579"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2014.5177"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2017.06.029"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23126"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22637"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22940"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2014.899347"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2014.975197"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2014.12.006"},{"key":"e_1_2_7_14_1","first-page":"2491","article-title":"Is vaginal fractional CO2 laser treatment effective in improving overactive bladder symptoms in post\u2010menopausal patients? 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