{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:32:41Z","timestamp":1785857561622,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Miramar Labs Inc."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Hyperhidrosis (HH) is associated with impairments in quality of life (QOL) and elevated anxiety. Microwave thermolysis is a newer treatment that reduces sweating, yet effects on QOL and emotional symptoms have not been examined. Two treatment sessions are recommended to achieve 80% amelioration of clinical HH. We hypothesized that microwave thermolysis would reduce sweat severity, improve QOL, and reduce anxiety in young adults suffering from axillary HH in a prospective clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>We enrolled 24 young adults (mean age\u2009=\u200923.57 years, 54% female) with elevated scores on the Hyperhidrosis Disease Severity Scale. All participants received one session of microwave thermolysis, and 83% received two sessions. Participants completed measures of sweat severity, QOL, generalized anxiety, social anxiety, social avoidance, and anxious\/depressive mood symptoms at baseline; post\u2010first treatment; and following second treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, all participants had severe sweating; 87.5% had impaired QOL, 75% had elevated social anxiety, 50% with generalized anxiety, 48% with social avoidance, and 38% with anxious\/depressed mood. Paired samples <jats:italic>t<\/jats:italic> tests indicated significant improvements from baseline to first procedure, including decreased sweating (<jats:italic>t<\/jats:italic>(21)\u2009=\u20095.68, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), improved QOL (<jats:italic>t<\/jats:italic>(23)\u2009=\u20094.97, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and decreased generalized anxiety (<jats:italic>t<\/jats:italic>(23)\u2009=\u20098.11, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), social anxiety (<jats:italic>t<\/jats:italic>(22)\u2009=\u20094.55, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), mood symptoms (<jats:italic>t<\/jats:italic>(21)\u2009=\u20093.81, <jats:italic>P<\/jats:italic>\u2009=\u20090.001), and social avoidance (<jats:italic>t<\/jats:italic>(22)\u2009=\u20093.12, <jats:italic>P<\/jats:italic>\u2009=\u20090.005). After second treatment, further improvements were noted in sweating (<jats:italic>t<\/jats:italic>(18)\u2009=\u20093.28, <jats:italic>P<\/jats:italic>\u2009=\u20090.004) and QOL (<jats:italic>t<\/jats:italic>(18)\u2009=\u20093.83, <jats:italic>P<\/jats:italic>\u2009=\u20090.003), and a marginal trend for generalized anxiety (<jats:italic>t<\/jats:italic>(19)\u2009=\u20091.96, <jats:italic>P<\/jats:italic>\u2009=\u20090.064).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were significant improvements in sweat severity, skin\u2010specific QOL, generalized anxiety, social anxiety, anxious\/depressive symptoms, and social avoidance. The majority of the psychosocial benefit appears to emerge after one treatment of microwave thermolysis, whereas the level of sweat severity and QOL continued to show further improvements after a second treatment. Results would suggest that although two microwave thermolysis sessions are needed for maximal treatment optimization of axillary HH, patients may experience significant benefits in improving psychosocial functioning after just one session. Lasers Surg. Med. \u00a9 2020 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23229","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T09:55:04Z","timestamp":1584352504000},"page":"842-847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Microwave Thermolysis Reduces Generalized and Social Anxiety in Young Adults With Axillary Hyperhidrosis"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3687-782X","authenticated-orcid":false,"given":"Carisa","family":"Parrish","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Johns Hopkins University School of Medicine  Baltimore Maryland 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Waldbaum","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins Hospital  Baltimore Maryland 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-1036","authenticated-orcid":false,"given":"Daniel","family":"Coleman","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Johns Hopkins University School of Medicine  Baltimore Maryland 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carley","family":"Blevins","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Johns Hopkins University School of Medicine  Baltimore Maryland 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Johns Hopkins University School of Medicine  Baltimore Maryland 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins Hospital  Baltimore Maryland 21287"},{"name":"Division of Thoracic Surgery Johns Hopkins University School of Medicine  Baltimore Maryland 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecily","family":"Ober","sequence":"additional","affiliation":[{"name":"Rosalind Franklin Medical School  Chicago Illinois 60064"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layla","family":"Hudhud","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Johns Hopkins University School of Medicine  Baltimore Maryland 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Oncology Johns Hopkins University School of Medicine  Baltimore Maryland 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace","family":"Griffin","sequence":"additional","affiliation":[{"name":"Emmes Company LLC  Rockville Maryland 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunmi","family":"Chew","sequence":"additional","affiliation":[{"name":"Miramar Labs Inc.  Santa Clara California 95051"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Chen","sequence":"additional","affiliation":[{"name":"Miramar Labs Inc.  Santa Clara California 95051"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Brock","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins Hospital  Baltimore Maryland 21287"},{"name":"Division of Thoracic Surgery Johns Hopkins University School of Medicine  Baltimore Maryland 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"issue":"5","key":"e_1_2_6_2_1","first-page":"5","article-title":"Primary focal hyperhidrosis: Scope of the problem","volume":"79","author":"Glaser DA","year":"2007","journal-title":"Cutis"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1697-9"},{"key":"e_1_2_6_4_1","first-page":"415","article-title":"Efficacy of miniuniportal video\u2010assisted thoracoscopic selective sympathectomy (ramicotomy) for the treatment of severe palmar and axillar hyperhidrosis","volume":"67","author":"Akil A","year":"2018","journal-title":"Thorac Cardiovasc Surg"},{"key":"e_1_2_6_5_1","first-page":"420","article-title":"Evaluation of quality of life: Functional assessment of chronic illness therapy after thoracic sympathectomy for palmar hyperhidrosis","volume":"67","author":"Dobosz L","year":"2018","journal-title":"Thorac Cardiovasc Surg"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.04.063"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2011.01.059"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-69912009000100005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/0100-69912016005013"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2006.05.018"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy211"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06334.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0105"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13291"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21142"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21142"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02250.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02375.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2013.807114"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.10.1005"},{"issue":"8","key":"e_1_2_6_21_1","first-page":"908","article-title":"A comprehensive approach to the recognition, diagnosis, and severity\u2010based treatment of focal hyperhidrosis: Recommendations of the canadian hyperhidrosis advisory committee","volume":"33","author":"Solish N","year":"2007","journal-title":"Dermatol Surg"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2004.09113.x"},{"key":"e_1_2_6_23_1","first-page":"177","article-title":"The measurement of affects: Depression and anxiety","volume":"7","author":"Zung WWK","year":"1974","journal-title":"Mod Trends Pharmacopsychiatry"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.176.4.379"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.10.202"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1157\/13070805"},{"key":"e_1_2_6_27_1","volume-title":"Manual for the ASEBA Adult Forms & Profiles","author":"Achenbach TM","year":"2003"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.11"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.71.6.1058"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23073"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.23229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.23229","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T04:21:01Z","timestamp":1693887661000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,16]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/lsm.23229"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23229","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,16]]},"assertion":[{"value":"2020-02-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}