{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:05:33Z","timestamp":1777478733687,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,3,22]],"date-time":"2020-03-22T00:00:00Z","timestamp":1584835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Complex regional pain syndrome (CRPS) is defined as an extreme and chronic pain condition, and photobiomodulation has relevance as a complementary treatment for CRPS. The objective of this study was to verify the effects of photobiomodulation (PBMT) therapy protocols at two wavelengths 660 and 830\u2009nm, associated or not to nicotine in complex regional pain syndrome type I (CRPS\u2010I).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Sixty\u2010four Swiss mice were divided into the following groups: (i) Naive, (ii) Sham, (iii) Control, (iv) 660\u2009nm, (v) 830\u2009nm, (vii) Nicotine, (vii) Nicotine\/660\u2009nm, and (viii) Nicotine\/830\u2009nm. CRPS\u2010I was induced in an experimental ischemia\/reperfusion model by affixing an elastic ring, proximal to the ankle joint of the right hind mouse paw, for 3\u2009hours. Nicotine, in the respective groups was administered for 28 days prior to the induction of CRPS\u2010I. PBMT was applied immediately after the procedure and for 20 consecutive days. The animals were evaluated for mechanical hyperalgesia, thermal hyperalgesia, paw edema at baseline and for 7, 14, and 21 days. Statistical analyses comprised a mixed\u2010effects model, using the Tukey post hoc test (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PBMT wavelengths in 660 and 830\u2009nm groups had beneficial effects (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in reducing mechanical and thermal hyperalgesia, but the effects at 660\u2009nm were significantly better than 830\u2009nm. At reducing edema, both wavelengths had significant\u00a0effects statistically, absolutely no difference between them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of PBMT (660 and 830\u2009nm) was effective in reducing mechanical hyperalgesia and thermal hyperalgesia; however, PBMT at 660\u2009nm generated significant results. In reducing edema, both wavelengths had similar effects, which were significant statistically. The deleterious effects of nicotine were evident statistically and were softened when treated with PBMT (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Lasers Surg. Med. \u00a9 2020 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23240","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T04:54:20Z","timestamp":1584939260000},"page":"890-896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Photobiomodulation Decreases Hyperalgesia in Complex Regional Pain Syndrome: An Experimental Mouse Model Subjected to Nicotine"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2068-5476","authenticated-orcid":false,"given":"Mariana","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Postgraduate Program in Rehabilitation Sciences Federal University of Santa Catarina (LARAL\/UFSC) Rua Pedro Jo\u00e3o Pereira, 150 Ararangu\u00e1 Santa Catarina CEP 88905\u2010120 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon 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