{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T03:30:52Z","timestamp":1764646252371,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102018R1C1B5042271"],"award-info":[{"award-number":["NRF\u20102018R1C1B5042271"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Combined sequential treatments with multiple modalities such as lasers and soft\u2010tissue fillers are commonly required for the treatment of atrophic acne scars. Recently, fractional treatment with picosecond\u2010domain lasers has proven to be effective for skin rejuvenation and scar treatment. However, little is known about the effects of picosecond\u2010domain fractional laser treatment over hyaluronic acid fillers (HAFs). We aimed to evaluate the <jats:italic>in vivo<\/jats:italic> tissue responses to 1064\u2009nm picosecond\u2010domain fractional neodymium:yttrium\u2010aluminum\u2010garnet (Nd:YAG) laser treatments using microlens array (MLA) applied over pre\u2010injected HAF in rats. In addition, we evaluated the efficacy and safety of this combined same\u2010day treatment for atrophic acne scars in patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Sprague\u2013Dawley rats were subjected to 1064\u2009nm picosecond\u2010domain fractional Nd:YAG laser treatment immediately after HAF dermal injection. Skin specimens were histologically evaluated on days 0, 7, and 21. In a clinical study, 36 patients with acne scars were treated concurrently with 1064\u2009nm MLA\u2010type picosecond lasers and HAFs. The patients were scheduled to receive two consecutive treatments at 4\u2010week intervals, with a follow\u2010up visit at 12 weeks after the final treatment. Acne scar photographs were graded using the Goodman and Baron's qualitative and quantitative scales at baseline and 12 weeks post\u2010procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Picosecond\u2010domain fractional laser treatment immediately after the dermal injection of HAF into rats did not cause any histological changes in the filler or surrounding skin. In a clinical study, treated subjects (<jats:italic>n<\/jats:italic>\u2009=\u200936) achieved significant improvement in acne scars and patient satisfaction. No serious adverse events were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combined picosecond laser and HAF treatment were proven to be safe and effective based on <jats:italic>in vivo<\/jats:italic> and clinical study results. Facial rejuvenation and scar treatment using a picosecond\u2010domain fractional laser may be performed immediately after HAF injection. Lasers Surg. Med. \u00a9 2020 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23254","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T05:39:35Z","timestamp":1588225175000},"page":"928-934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Picosecond\u2010Domain Fractional Laser Treatment Over Hyaluronic Acid Fillers: In Vivo and Clinical Studies"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8399-8456","authenticated-orcid":false,"given":"Jung E.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Soonchunhyang University Cheonan Hospital  31, Suncheonhyang 6\u2010gil Cheonan Chungcheongnam\u2010do 31151 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Y.","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Soonchunhyang University Cheonan Hospital  31, Suncheonhyang 6\u2010gil Cheonan Chungcheongnam\u2010do 31151 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Soonchunhyang University Cheonan Hospital  31, Suncheonhyang 6\u2010gil Cheonan Chungcheongnam\u2010do 31151 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Soonchunhyang University Cheonan Hospital  31, Suncheonhyang 6\u2010gil Cheonan Chungcheongnam\u2010do 31151 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun J.","family":"Kim","sequence":"additional","affiliation":[{"name":"CNP Skin Clinic, Cheonan  147, Gosokcheol\u2010daero Asan Chungcheongnam\u2010do 31470 Republic of 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