{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:05:25Z","timestamp":1788998725817,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Until recently, quality\u2010switched nanosecond lasers have been the workhorse lasers in treating pigmented lesions. However, the recently commercialized picosecond lasers have provided physicians with a novel method to manage pigmented lesions. Most recently, the first picosecond laser with a 730\u2010nm wavelength was developed to specifically target melanin and melanocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>We report on two Asian patients with freckles, lentigines, and melasma who were successfully treated with a novel 730\u2010nm Ti:Sapphire picosecond laser (Picoway\u00ae; Syneron Candela, Corp). The clinical outcome was measured by the global percent of clearance, which was evaluated by blinded observers by comparing the post\u2010treatment photographs with the baseline photographs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both patients, a significant pigmentary reduction was achieved with only one treatment session. In both patients, the treatments were well tolerated with minimal discomfort even without topical anesthesia. No post\u2010inflammatory hyperpigmentation or repigmentation was observed until the 6\u2010week follow\u2010up. The pigmentary conditions treated included freckles, lentigines, and melasma. Both subjects showed clinical improvement, with the best results observed for the treatment of freckles such that 95% of the lesions achieved excellent response (75\u201394% lightening).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this case report indicate that a novel 730\u2010nm Ti:Sapphire picosecond laser may be effective and safe in treating pigmentary disorders in darker\u2010skinned patients. Therefore, further well\u2010designed, prospective clinical trials are warranted to establish the potential of 730\u2010nm picosecond lasers and determine the optimal treatment parameters in comparison to existing laser and light modalities. Lasers Surg. Med. \u00a9 2020 Wiley Periodicals LLC<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23261","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T05:20:11Z","timestamp":1589520011000},"page":"923-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Successful Treatment of Pigmentary Disorders in Asians With a Novel 730\u2010nm Picosecond Laser"],"prefix":"10.1002","volume":"52","author":[{"given":"Sang Ju","family":"Lee","sequence":"first","affiliation":[{"name":"Yonsei Star Skin &amp; Laser Clinic Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Sung","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine Chung\u2010Ang University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5277-5823","authenticated-orcid":false,"given":"Jun Ki","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine Chung\u2010Ang University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine Chung\u2010Ang University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Jun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine Chung\u2010Ang University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001697"},{"key":"e_1_2_7_3_1","article-title":"A systematic review of picosecond laser in dermatology: evidence and recommendations","author":"Wu DC","journal-title":"Lasers Surg 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